Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex.
Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex.
复制标题
在视觉皮层中由不同的皮质 - 传和检测敏感性控制的敏感性。
DOI：
10.7554/elife.59247
复制
发表时间：
2020-12-07
期刊：
影响因子：
7.7
通讯作者：
Scanziani M
中科院分区：
文献类型：
--
作者：
Ruediger S;Scanziani M
脊椎动物可以根据其行为产生的结果在检测到视觉刺激时改变其行为。这种目标导向的行为涉及到进化中保守的大脑结构，如纹状体和视顶盖，它们接收来自周边的上行视觉输入。然而，在哺乳动物中，这些结构也通过引起离皮质投射的神经元接收来自视觉皮层（VC）的下行视觉输入。离皮质神经元在视觉引导、目标导向行为中的功能尚不清楚。在这里，我们解决了两个群体的离皮质神经元在小鼠VC的学习和视觉检测任务的性能的影响。我们发现，纹状体投射神经元的消融降低了学习速度，而上级丘投射神经元的消融不影响学习，但降低了检测灵敏度。不同的离皮质神经元在控制学习速度和检测灵敏度之间的这种功能分离表明，即使在简单的目标导向行为中，离皮质通路也有适应性贡献。
Vertebrates can change their behavior upon detection of visual stimuli according to the outcome their actions produce. Such goal-directed behavior involves evolutionary conserved brain structures like the striatum and optic tectum, which receive ascending visual input from the periphery. In mammals, however, these structures also receive descending visual input from visual cortex (VC), via neurons that give rise to cortico-fugal projections. The function of cortico-fugal neurons in visually guided, goal-directed behavior remains unclear. Here, we address the impact of two populations of cortico-fugal neurons in mouse VC in the learning and performance of a visual detection task. We show that the ablation of striatal projecting neurons reduces learning speed, whereas the ablation of superior colliculus projecting neurons does not impact learning but reduces detection sensitivity. This functional dissociation between distinct cortico-fugal neurons in controlling learning speed and detection sensitivity suggests an adaptive contribution of cortico-fugal pathways even in simple goal-directed behavior.