pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.
pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.
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DOI：
10.3201/eid2303.161034
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发表时间：
2017-03
影响因子：
11.8
通讯作者：
Gandhi NR
中科院分区：
文献类型：
--
作者：
Allana S;Shashkina E;Mathema B;Bablishvili N;Tukvadze N;Shah NS;Kempker RR;Blumberg HM;Moodley P;Mlisana K;Brust JC;Gandhi NR
虽然吡嗪酰胺通常用于结核病治疗，但药物敏感性测试并不常规可用。我们在南非和格鲁吉亚分离的70%多药耐药结核分枝杆菌和96%广泛耐药结核分枝杆菌中发现了pncA基因多态性。在将吡嗪酰胺用于耐药结核病治疗方案之前，应谨慎评估吡嗪酰胺的敏感性。
Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.