Maternal hemoglobin at 27-29 weeks' gestation and severity of pre-eclampsia
Maternal hemoglobin at 27-29 weeks' gestation and severity of pre-eclampsia
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DOI：
10.3109/14767058.2014.961006
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发表时间：
2015-01-01
影响因子：
1.8
通讯作者：
Kametas, Nikos A.
中科院分区：
文献类型：
--
作者：
Cordina, Mark;Bhatti, Sadia;Kametas, Nikos A.
目的：探讨妊娠27 ~ 29周母体血红蛋白浓度（Hb）与先兆子痫（PE）严重程度的关系。方法：这是一项回顾性研究，对497例妊娠发生PE的27-29周孕妇Hb和497例妊娠结局正常的健康对照进行研究。采用多元回归分析，以分娩妊娠、出生体重、围生期孕妇肌酐、天冬氨酸转氨酶和血小板计数异常发生率为依据，探讨HB与产妇特征及PE严重程度的相关性。结果：PE组与对照组的中位Hb无显著差异。PE组的多元回归分析显示，非洲-加勒比种族、分娩时妊娠、母体血小板计数52.5百分位数和出生体重对Hb有显著的预测作用，但血清肌酐或天冬氨酸转氨酶高于97.5百分位数则无显著预测作用。在小胎龄和大胎龄新生儿中均观察到Hb升高。结论：在PE中，27-29周的Hb受出生体重、母体特征和血小板计数的影响。
Objective: To examine the relationship between maternal hemoglobin concentration (Hb) at 27-29 weeks' gestation and severity of pre-eclampsia (PE).Methods: This was a retrospective study of maternal Hb at 27-29 week in 497 pregnancies that developed PE and 497 healthy controls with normal pregnancy outcomes. Multiple regression analysis was used to examine the association between HB and maternal characteristics and severity of PE classified according to gestation at delivery, birth weight and prevalence of abnormal peripartum maternal creatinine, aspartate transaminase and platelet count.Results: There was no significant difference in median Hb between the PE and control groups. Multiple regression analysis in the PE group showed that significant prediction for Hb was provided by Afro-Caribbean race, gestation at delivery, maternal platelet count 52.5th percentile and birth weight, but not serum creatinine or aspartate transaminase above the 97.5th percentile. Increased Hb was observed in both small and large for gestational age neonates.Conclusion: In PE, Hb at 27-29 weeks is influenced by birth weight, maternal characteristics and platelet count.