Optical survey of vagus nerve-related neuronal circuits in the embryonic rat brainstem.
Optical survey of vagus nerve-related neuronal circuits in the embryonic rat brainstem.
复制标题
胚胎大鼠脑干中迷走神经相关神经元回路的光学调查。
DOI：
10.1016/j.neulet.2012.12.013
复制
发表时间：
2013
影响因子：
2.5
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Momose-Sato;Y.;Nakamori;T.;Mullah;S. H.- E.-R. and Sato;K.
使用电压敏感染料NK 2761的多位点光学记录技术来研究E16期大鼠脑干中与迷走神经（N.X）相关的神经元网络的功能组织。当我们刺激N.X时，除了刺激侧迷走神经感觉核（孤束核（NTS））的反应外，还在双侧检测到其他反应区域。这些区域中的光学信号的特征表明它们对应于迷走神经通路的第二/高阶核中的神经活动。第一个区域位于脑桥水平。基于形态学信息，我们认为，这一领域对应的臂旁核（PBN），它接收输入的NTS。第二个区域位于NTS和PBN之间。我们认为，这一地区是A5去甲肾上腺素能组。这些结果表明，N. X相关的神经网络建立类似于成人模式从早期发育阶段。
The multiple-site optical recording technique with a voltage-sensitive dye, NK2761, was used to survey the functional organization of neuronal networks related to the vagus nerve (N.X) in the E16-stage rat brainstem. When we stimulated N.X, in addition to the responses in the vagal sensory nucleus (nucleus of the tractus solitarius (NTS)) on the stimulated side, other response areas were bilaterally detected. Characteristics of the optical signals in these areas suggested that they correspond to neural activity in the second/higher-ordered nucleus of the vagal pathway. The first area was located at the level of the pons. Based upon morphological information, we suggest that this area corresponds to the parabrachial nucleus (PBN), which receives inputs from the NTS. The second area was located between the NTS and the PBN. We suggest that this area is the A5 noradrenergic group. These results suggest that the N.X-related neural networks are established similarly to the adult pattern from an early developmental stage.