Brain changes associated with impaired attention function in chronic pain
Brain changes associated with impaired attention function in chronic pain
复制标题
慢性疼痛中注意力功能受损相关的大脑变化
DOI：
10.1016/j.bandc.2021.105806
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发表时间：
2021
影响因子：
2.5
通讯作者：
Yamawaki Shigeto
中科院分区：
文献类型：
--
作者：
Yoshino Atsuo;Otsuru Naofumi;Okada Go;Tanaka Keisuke;Yokoyama Satoshi;Okamoto Yasumasa;Yamawaki Shigeto
注意功能被认为在慢性疼痛中很重要，慢性疼痛的病理与认知-情绪成分密切相关。然而，很少有关于注意功能与慢性疼痛之间关系的神经影像学研究。我们使用静息状态fMRI （rs-fMRI）数据的功能连接分析方法和注意网络测试修订（ANT-R）来阐明慢性疼痛的注意相关病理。我们对26名慢性疼痛（躯体形式疼痛障碍）患者和28名年龄匹配的健康对照者进行了rs-fMRI和ANT-R。效度效应（ANT-R的一个组成部分）组间存在显著差异（F1,46= 5.91,p= 0.019），慢性疼痛组反应时间较慢。慢性疼痛患者的左脑岛和左额叶区脑连通性下降（pFWE< 0.05），且连通性与效度效应呈负相关（r= - 0.29，排列检验p= 0.033）。慢性疼痛组右脑岛和左颞回功能连接强度下降（pFWE< 0.05）。我们认为，慢性疼痛患者的注意功能控制不良是由左脑岛和左额叶区域的功能连接缺陷引起的。
Attention function is thought to be important in chronic pain, with the pathology of chronic pain closely associated with cognitive–emotional components. However, there have been few neuroimaging studies of the relationship between attention function and chronic pain. We used the method of functional connectivity analysis for resting-state fMRI (rs-fMRI) data and the Attention Network Test-Revision (ANT-R) to clarify the attention-related pathology of chronic pain. We performed rs-fMRI and ANT-R on a group of 26 chronic pain (somatoform pain disorder) patients and 28 age-matched healthy controls. A significant group difference in validity effects, a component of ANT-R, emerged (F1,46= 5.91,p= 0.019), and the chronic pain group exhibited slower reaction times. Decreased brain connectivity of the left insula and left frontal regions was confirmed in chronic pain patients (pFWE< 0.05), and connectivity was negatively correlated with validity effects (r= −0.29, permutation testp= 0.033). Further, decreased functional connectivity strength of the right insula and left temporal gyrus in the chronic pain group were confirmed (pFWE< 0.05). We conclude that poor control of attention function results from deficits of functional connectivity in the left insula and left frontal regions in chronic pain.