Novel metal ion-mediated complex imprinted membrane for selective recognition and direct determination of naproxen in pharmaceuticals by solid surface fluorescence
Novel metal ion-mediated complex imprinted membrane for selective recognition and direct determination of naproxen in pharmaceuticals by solid surface fluorescence
复制标题
新型金属离子介导的复合印迹膜用于固体表面荧光选择性识别和直接测定药物中萘普生
DOI：
10.1016/j.talanta.2013.07.022
复制
发表时间：
2013-11-15
期刊：
影响因子：
6.1
通讯作者：
Li, Gongke
中科院分区：
文献类型：
--
作者：
Lian, Haixian;Hu, Yuling;Li, Gongke
将复合印迹聚合物(CIP)固定在聚丙烯膜上，制备了一种新型的金属离子介导的复合印迹膜(CIM)。CIP是一种新型的印迹材料，它以铜(II)离子和萘普生为模板，通过配位作用而不是氢键作用来改善膜在水介质中的选择性识别和富集性能，使CIP成为一种很有前途的模拟生物识别过程的材料。以CIM为识别材料，建立了一种简便、灵敏、选择性好的固体表面荧光法测定药品中的萘普生。在最佳条件下，CIM对萘普生具有较大的吸附容量和较高的选择性。方法的线性范围为0.50~20 mg/L，检出限为0.11 mg/L，可用于药品中萘普生的分析。加样回收率分别为85.0%和89.1%，RSD分别为9.2%和12.0%。测定结果与高效液相色谱仪测定结果一致。CIM集萃取、浓缩、检测为一体，可提高分析过程的效率。(C)2013爱思唯尔B.V.保留所有权利。
A novel metal ion-mediated complex imprinted membrane (CIM) was prepared by immobilization of complex imprinted polymer (CIP) onto a polypropylene membrane. CIP was introduced as a novel imprinted material using a "complex template" constructed with Cu (II) ion and naproxen that could improve the selective recognition and enrichment properties of the membrane in water medium based on the coordination interaction rather than hydrogen bonding interactions, which could make CIP a promising material to mimic biological recognition process. A simple, sensitive and selective solid surface fluorescence method was proposed for the determination of naproxen in pharmaceuticals sample, using the CIM as the recognition material. Under the optimum conditions, the CIM exhibited large adsorption capacity and high selectivity to naproxen. A good linearity was obtained in the range of 0.50-20 mg/L with an estimated detection limit of 0.11 mg/L. Finally, the proposed method was applied to the analysis of naproxen in pharmaceuticals without complicated pretreatment. The recoveries were 85.0% and 89.1% and the RSDs were 9.2% and 12.0%. The results were consistent with that obtained by high performance liquid chromatography. CIM integrated extraction, concentration, and detection into one-step, which could make the analytical procedure more efficient. (C) 2013 Elsevier B.V. All rights reserved.