4-Hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects?
4-Hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects?
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DOI：
10.1080/15216540600686896
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发表时间：
2006-05-01
期刊：
影响因子：
4.6
通讯作者：
Niki, E
中科院分区：
文献类型：
--
作者：
Chen, ZH;Niki, E
文章讨论了4-羟基壬烯醛(4-HNE)在调节多种细胞过程和激活许多信号通路中的作用，包括那些有助于适应性细胞保护反应和细胞死亡的信号通路。4-HNE是脂质过氧化的主要终产物之一。它还可以作为信号分子，调节蛋白激酶B和C、丝裂原激活的蛋白激酶和酪氨酸激酶受体。
The article discusses the role 4-hydroxynonenal (4-HNE) in modulating a wide variety of cellular processes and activating numerous signaling pathways including those that contribute to adaptive cytoprotective responses and cell death. 4-HNE is one of the major end products of lipid peroxidation. It can also act as a signaling molecule and modulates protein kinase B and C, mitogen-activated protein kinase, and tyrosine kinase receptors.