Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis
Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis
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DOI：
10.1038/sj.ejcn.1602420
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发表时间：
2006-09
影响因子：
4.7
通讯作者：
H. Yamanaka-Okumura;Taki Nakamura;H. Takeuchi;Hidenori Miyake;Toshiko Katayama;H. Arai;Y. Taketani;Masahiko Fujii;M. Shimada;E. Takeda
中科院分区：
文献类型：
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作者：
H. Yamanaka-Okumura;Taki Nakamura;H. Takeuchi;Hidenori Miyake;Toshiko Katayama;H. Arai;Y. Taketani;Masahiko Fujii;M. Shimada;E. Takeda
目的：探讨200千卡饭团宵夜对肝硬化患者能量代谢的影响。营养代谢受损与肝硬化有关，经常少餐可预防早发性饥饿，并维持这些患者的营养。研究对象：本研究招募了21名肝硬化患者和26名对照组（control）。患者随后接受LES （LC-LES）和非LES方案（LC-NLES）治疗。方法：采用间接量热法于0830、1130和1430测定小鼠静息能量消耗和呼吸商（RQ）。在能量代谢测量之前测量血糖和非酯化脂肪酸（NEFA）。正常饮食包括3顿正餐，分别在早上9点、12点、18点和21点进食。对照组和LC-NLES组只吃正餐，而LC-LES组吃三餐加200千卡的正餐，持续7天。对照组、LC-NLES组和LC-LES组总能量摄取量无显著差异。结果：0830时，LC-NLES组呼吸商明显低于对照组。LC-LES组呼吸商值较LC-NLES组显著升高。餐后2 h(1130和1430)，对照组、LC-NLES组和LC-LES组的RQ值无显著差异。禁食过夜后LC-LES的非酯化脂肪酸含量低于LC-NLES。结论：一个200千卡饭团可改善肝硬化患者的营养代谢。
Objective:This study investigates the effects of a late evening snack (LES), of 200 kcal of rice ball, on energy metabolism in cirrhotic patients. Impaired nutritional metabolism has been associated with cirrhosis, and frequent intake of small meals may prevent early-onset starvation, and maintain nourishment in these patients.Subjects:Twenty-one cirrhotic patients and 26 control subjects (Control) were recruited for this study. Patients were subsequently treated by LES (LC-LES) and by a non-LES regimen (LC-NLES).Method:Resting energy expenditure and respiratory quotient (RQ) were assessed by indirect calorimetry at 0830, 1130 and 1430. Blood glucose and non-esterified fatty acids (NEFA) were measured just before the energy metabolism measurements. The regular diet included three major meals and LES, at 0900, 1200, 1800 and 2100, respectively. The Control and LC-NLES groups received only the major meals, whereas the LC-LES group received three meals plus 200 kcal LES for 7 days. There was no difference in the total energy intake among Control, LC-NLES and LC-LES groups.Results:Respiratory quotient in LC-NLES was significantly lower than that of Control at 0830. Respiratory quotient value in LC-LES significantly elevated from that in LC-NLES. The RQ values did not differ among Control, LC-NLES and LC-LES at 2 h after the meal (1130 and 1430). Non-esterified fatty acids in LC-LES were lower than that in LC-NLES after overnight fasting.Conclusions:The ingestion of a 200 kcal rice ball LES can improve the nutritional metabolism in cirrhotic patients.