Sex-specific assembly of a dosage compensation complex on the nematode X chromosome
Sex-specific assembly of a dosage compensation complex on the nematode X chromosome
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DOI：
10.1126/science.274.5293.1736
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发表时间：
1996-12-06
期刊：
影响因子：
56.9
通讯作者：
Meyer, BJ
中科院分区：
文献类型：
--
作者：
Chuang, PT;Lieb, JD;Meyer, BJ
在线虫、果蝇和哺乳动物中，剂量补偿通过全染色体调控机制平衡两性间的X染色体基因表达，该机制在一种性别中发挥作用以调节X连锁转录本的水平。在此，在线虫秀丽隐杆线虫中鉴定出一种剂量补偿复合物，它降低雌雄同体两条X染色体的转录本水平。该复合物至少包含四种蛋白质，包括剂量补偿基因dpy - 26和dpy - 27的产物。该复合物特异性定位于雌雄同体的X染色体是由XX特异性调控基因决定的，这些基因协同控制性别决定和剂量补偿。
In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites, This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.