Single-unit and 2-deoxyglucose studies of side inhibition in macaque striate cortex.
Single-unit and 2-deoxyglucose studies of side inhibition in macaque striate cortex.
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DOI：
10.1073/pnas.88.16.7071
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发表时间：
1991-08
影响因子：
11.1
通讯作者：
R. Born;R. Tootell
中科院分区：
文献类型：
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作者：
R. Born;R. Tootell
在定位猕猴纹状皮质第二层和第三层神经元的空间频率调谐的研究过程中，我们发现，与单条、边或定界格栅相比，斑点间区域高比例(70%)的细胞对全场格栅的反应较差。这最常见的原因是侧面抑制，在这种情况下，增加放置在细胞感受野内的格栅的循环次数会导致对反应的渐进性抑制。然而，定量感受野映射显示，这种抑制可以发生在被杆状突触激活的区域内，也可以发生在它之外。这种抑制似乎是方向选择性的，因为如果中心光栅贴片具有相似的取向，环绕光栅在抑制对该贴片的响应方面更有效。2-脱氧葡萄糖实验证实，侧面抑制在第2层和第3层的间质中非常普遍，并表明它在第4A层到第6层中减少或缺失。由于纹状皮质的第2层和第3层是V2区和V2区以外的皮质投射的主要来源，这些板层中的侧停现象的流行对皮质视觉功能的理论有一定的意义。侧面停止的斑点间单元格可以充当过滤纹理或噪声表面中的冗余信息的“轮廓传递过滤器”，将后续的表格处理集中在对应于对象边界的对比度上。
In the course of studies to map spatial frequency tuning of neurons in layers 2 and 3 of macaque striate cortex, we found that a high proportion (70%) of cells in the interblob regions responded poorly to full-field gratings, compared with responses to single bars, edges, or delimited gratings. This was most often due to side inhibition, in which increasing the number of cycles of a grating placed within the cell's receptive field causes progressive inhibition of response. Quantitative receptive-field mappings showed, however, that the inhibition can occur within the region activated by a bar, as well as beyond it. The inhibition appears to be orientation-selective, in that a surround grating was more effective at inhibiting the response to a center grating patch if it was of similar orientation. 2-Deoxyglucose experiments confirmed that side inhibition is very widespread in the interblobs of layers 2 and 3 and suggested that it is reduced or lacking in layers 4A through 6. Since layers 2 and 3 of striate cortex are the major source of cortical projections to area V2 and beyond, the prevalence of side stopping in these laminae has implications for theories of cortical visual function. Side-stopped interblob cells may be acting as "contour-pass filters" that filter out redundant information in textured or noisy surfaces, focusing subsequent form processing on contrasts corresponding to object boundaries.