Associations between ambient air pollution and daily mortality among persons with diabetes and cardiovascular disease
Associations between ambient air pollution and daily mortality among persons with diabetes and cardiovascular disease
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DOI：
10.1016/j.envres.2005.04.007
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发表时间：
2006-02-01
影响因子：
8.3
通讯作者：
Brook, JR
中科院分区：
文献类型：
--
作者：
Goldberg, MS;Burnett, RT;Brook, JR
背景资料：最近的研究表明，患有糖尿病和心血管疾病的人可能更容易受到空气污染的短期影响。我们在加拿大魁北克的蒙特利尔进行了这一死亡率时间序列研究，以证实这些观察结果，并确定糖尿病患者谁有其他健康状况也在死亡的风险较高时，空气pollution increases.Methods和results：在一项分析中，我们相关的每日糖尿病死亡（使用的根本原因）的颗粒物和气体污染物的每日浓度。在另一项分析中，我们通过从通用魁北克健康保险计划的账单和处方数据中确定死亡前1年诊断为糖尿病和其他主要健康状况的受试者来创建亚组。分析使用了参数对数线性泊松模型，该模型根据长期时间趋势和每日天气状况进行了调整。我们发现大多数空气污染物与糖尿病每日死亡率之间存在正相关，以及在死亡前一年诊断为糖尿病的受试者之间存在正相关。在后一组受试者中，通常在温暖的季节发现更大的影响，特别是在患有糖尿病和患有任何心血管疾病，慢性冠状动脉疾病和动脉粥样硬化的受试者中。我们没有发现仅患有糖尿病的人之间存在关联的证据（即，没有癌症、心血管疾病或下呼吸道疾病）。结论：这些数据表明，糖尿病患者同时患有心血管疾病可能容易受到空气污染的短期影响。(c)2005年爱思唯尔公司All rights reserved.
Background: Recent studies suggest that persons with diabetes and with cardiovascular disease may be at higher risk for the short-term effects of air pollution. We carried out this mortality time series study in Montreal, Quebec, Canada to confirm these observations and to determine whether diabetics who had other health conditions were also at higher risk of dying when air pollution increases.Methods and results: In one analysis, we related daily deaths from diabetes (using the underlying cause) to daily concentrations of particles and gaseous pollutants. In another analysis, we created subgroups by identifying subjects diagnosed 1 year before death with diabetes and other major health conditions from billing and prescription data from the universal Quebec Health Insurance Plan. The analysis made use of parametric log-linear Poisson models that were adjusted for long-term temporal trends and daily weather conditions. We found positive associations between most air pollutants and daily mortality from diabetes as well as among subjects diagnosed with diabetes I year before death. In the latter group of subjects, greater effects were found generally in the warm season and especially among subjects who had diabetes and who also had any cardiovascular disease, chronic coronary disease, and atherosclerosis. We did not find evidence of associations among persons who only had diabetes (i.e., did not also have cancer, cardiovascular disease, or lower respiratory disease).Conclusions: These data indicate that individuals with diabetes who also have cardiovascular disease may be susceptible to the short-term effects of air pollution. (c) 2005 Elsevier Inc. All rights reserved.