Pregnancy complications and birth outcomes of pregnant women with urinary tract infections and related drug treatments
Pregnancy complications and birth outcomes of pregnant women with urinary tract infections and related drug treatments
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DOI：
10.1080/00365540601087566
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Czeizel, Andrew E.
中科院分区：
文献类型：
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作者：
Banhidy, Ferenc;Acs, Nandor;Czeizel, Andrew E.
在以前的研究中，孕妇尿路感染与早产率较高有关。这项研究的目的是检查这种关系，并评估最近的药物治疗的疗效。对匈牙利先天性畸形病例对照监测系统的基于人群的大型对照（无任何缺陷）数据集进行了评价。在38,151名新生儿中，2188名（5.7%）母亲在怀孕期间患有尿路感染，其中90%的母亲疾病有前瞻性和医学记录。先兆子痫和羊水过多的患病率与妊娠期尿路感染有关。妊娠期尿路感染的孕妇胎龄较短（0.1周），早产比例较高（10.4% vs 9.1%）。这些差异与尿路感染的严重程度相关。然而，母体尿路感染的早产诱导作用可以通过一些抗菌药物如氨苄西林、头孢氨苄和复方新诺明来预防。总之，孕妇在怀孕期间的尿路感染增加先兆子痫和羊水过多，以及早产率;然而，后者是可以通过适当的药物治疗来预防的。
Maternal urinary tract infections in pregnancy showed an association with a higher rate of preterm birth in previous studies. The aim of this study was to check this relationship, and in addition to evaluate the efficacy of recent medical treatments. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was evaluated. Of 38,151 newborn infants, 2188 (5.7%) had mothers with urinary tract infections during pregnancy, and 90% of these maternal diseases were prospectively and medically recorded. The prevalence of preeclampsia and polyhydramnios showed an association with urinary tract infections during pregnancy. Pregnant women with urinary tract infections in pregnancy had a somewhat shorter gestational age (0.1 week) and a higher proportion of preterm births (10.4% vs 9.1%). These differences were correlated with the severity of urinary tract infections. However, the preterm-inducing effect of maternal urinary tract infections is preventable by some antimicrobial drugs such as ampicillin, cefalexin and cotrimoxazole. In conclusion, maternal urinary tract infections during pregnancy increase pre-eclampsia and polyhydramnios, and in addition the rate of preterm birth; however, the latter is preventable by appropriate drug treatments.