(68)Ga-BBN-RGD PET/CT for GRPR and Integrin α(v)β(3) Imaging in Patients with Breast Cancer.
(68)Ga-BBN-RGD PET/CT for GRPR and Integrin α(v)β(3) Imaging in Patients with Breast Cancer.
复制标题
Ga-68-BBN-RGD PET/CT 用于乳腺癌患者的 GRPR 和整合素 α(v)β(3) 成像
作者：
Zhang J;Mao F;Niu G;Peng L;Lang L;Li F;Ying H;Wu H;Pan B;Zhu Z;Chen X
目的：探讨胃泌素释放肽受体（GRPR）和整合素αvβ3双靶向示踪剂68Ga-BBN-RGD在乳腺癌正电子发射断层扫描(PET)/计算机断层扫描（CT）成像中的应用价值。材料与方法：选取22例女性患者，其中16例为乳房x线筛查时疑似乳腺癌，6例为行乳腺癌根治性切除术。22例患者均于静脉注射68Ga-BBN-RGD后30-45 min行PET/CT检查。22例患者中有11例在2周内接受了68Ga-BBN PET/CT进行比较。最终诊断是基于手术切除或活检的组织病理学检查。结果：原发癌和转移癌均呈68Ga-BBN-RGD阳性积累。原发癌68Ga-BBN-RGD积累的T/B比值为2.10 ~ 9.44，腋窝淋巴结转移为1.10 ~ 3.71，远端淋巴结为3.80 ~ 10.7，肺转移为2.70 ~ 5.35，骨转移为3.17 ~ 22.8。对于原发性病变，ER阳性组68Ga-BBN-RGD PET的SUVmax高于ER阴性组（P < 0.01）。对于原发性和转移性病变，68Ga-BBN-RGD PET量化的SUVmean与GRPR表达和整合素αvβ3表达均有良好的相关性。结论：新型双整合素αvβ3和GRPR靶向放射性示踪剂在乳腺癌原发灶和转移灶中均有显著的摄取。68Ga-BBN-RGD PET/CT在鉴别原发性乳腺癌、腋窝淋巴结转移和远处转移方面都有重要价值。
Purpose: This study was to assess a gastrin-releasing peptide receptor (GRPR) and integrin αvβ3 dual targeting tracer 68Ga-BBN-RGD for positron emission tomography (PET)/computed tomography (CT) imaging of breast cancer and metastasis. Materials and Methods: Twenty-two female patients were recruited either with suspected breast cancer on screening mammography (n = 16) or underwent breast cancer radical mastectomy (n = 6). All the 22 patients underwent PET/CT at 30-45 min after intravenous injection of 68Ga-BBN-RGD. Eleven out of 22 patients also accepted 68Ga-BBN PET/CT within 2 weeks for comparison. A final diagnosis was made based on the histopathologic examination of surgical excision or biopsy. Results: Both the primary cancer and metastases showed positive 68Ga-BBN-RGD accumulation. The T/B ratios of 68Ga-BBN-RGD accumulation were 2.10 to 9.44 in primary cancer and 1.10 to 3.71 in axillary lymph node metastasis, 3.80 to 10.7 in distant lymph nodes, 2.70 to 5.35 in lung metastasis and 3.17 to 22.8 in bone metastasis, respectively. For primary lesions, the SUVmax from 68Ga-BBN-RGD PET in ER positive group was higher than that in ER negative group (P < 0.01). For both primary and metastatic lesions, SUVmean quantified from 68Ga-BBN-RGD PET correlated well with both GRPR expression and integrin αvβ3 expression. Conclusion: This study demonstrated significant uptake of a new type of dual integrin αvβ3 and GRPR targeting radiotracer in both the primary lesion and the metastases of breast cancer. 68Ga-BBN-RGD PET/CT may be of great value in discerning both primary breast cancers, axillary lymph node metastasis and distant metastases.