Impact of age on basal and diet-induced changes in sympathetic nervous system activity of Fischer rats.
Impact of age on basal and diet-induced changes in sympathetic nervous system activity of Fischer rats.
复制标题
年龄对费舍尔大鼠交感神经系统活动基础和饮食诱导变化的影响。
DOI：
10.1093/geronj/36.2.152
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Landsberg,L
中科院分区：
文献类型：
--
作者：
Rappaport,EB;Young,JB;Landsberg,L
进行研究以评估年龄对基础交感神经系统活动和饮食引起的交感神经活动变化的影响。测量各种组织中去甲肾上腺素的周转率作为交感神经系统活动的指标。在随意喂养的 3 至 24 个月大的雄性 Fischer 344 大鼠中，心脏、肝脏、肾脏或胰腺的去甲肾上腺素周转率不存在与年龄相关的差异。在相同的年龄范围内，喂食蔗糖的动物的器官中的去甲肾上腺素周转率高于禁食动物的器官中的去甲肾上腺素周转率。因此，饮食引起的交感神经活动变化在整个研究年龄范围内持续存在。
Studies were performed to assess the effect of age on basal sympathetic nervous system activity and on diet-induced changes in sympathetic activity. The rate of norepinephrine turnover in various tissues was measured as an index of sympathetic nervous system activity. In ad lib fed male Fischer 344 rats aged 3 to 24 months, there were no age-related differences in norepinephrine turnover in heart, liver, kidney or pancreas. Throughout the same age range, norepinephrine turnover was greater in organs of sucrose fed than in organs of fasted animals. Diet-induced changes in sympathetic activity thus persist throughout the age range studied.