Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort.
Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort.
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DOI：
10.1136/bmj-2022-071204
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发表时间：
2022-09-07
影响因子：
105.7
通讯作者：
Touvier, Mathilde
中科院分区：
文献类型：
--
作者：
Debras, Charlotte;Chazelas, Eloi;Sellem, Laury;Porcher, Raphael;Druesne-Pecollo, Nathalie;Esseddik, Younes;de Edelenyi, Fabien Szabo;Agaesse, Cedric;De Sa, Alexandre;Lutchia, Rebecca;Fezeu, Leopold K.;Julia, Chantal;Kesse-Guyot, Emmanuelle;Alles, Benjamin;Galan, Pilar;Hercberg, Serge;Deschasaux-Tanguy, Melanie;Huybrechts, Inge;Srour, Bernard;Touvier, Mathilde
研究来自所有饮食来源（饮料，但也包括桌面甜味剂，乳制品等）的人工甜味剂，总体和分子（糖精，乙酰磺胺酸钾和三氯蔗糖）与心血管疾病风险（总体，冠心病和脑血管疾病）之间的关联。基于人群的前瞻性队列研究（2009-21）。法国，初级预防研究。基于网络的NutriNet-Santé队列的103388名参与者（平均年龄42.2±14.4岁，79.8%为女性，904206人年）。通过重复的24小时饮食记录（包括工业产品的品牌名称）评估人工甜味剂的饮食摄入量和消费量。通过多变量校正考克斯风险模型评估甜味剂（编码为连续变量，log 10转换）与心血管疾病风险之间的关联。总人工甜味剂摄入量与心血管疾病风险增加相关（1502起事件，风险比1.09，95%置信区间1.01至1.18，P=0.03）;高消费者（高于性别特异性中位数）和非消费者的绝对发病率分别为346和314/10万人年。人工甜味剂与脑血管疾病风险更相关（777起事件，1.18，1.06至1.31，P=0.002;高消费者和非消费者的发病率分别为195和150/10万人年）。阿斯巴甜摄入与脑血管事件风险增加相关（1.17，1.03至1.33，P=0.02;高消费者和非消费者的发病率分别为186和151/10万人年），乙酰磺胺酸钾和三氯蔗糖与冠心病风险增加相关（730起事件;乙酰舒泛钾：1.40，1.06 - 1.84，P=0.02;发生率167和164;三氯蔗糖：1.31，1.00 - 1.71，P=0.05;发生率271和161）。这项大规模前瞻性队列研究的结果表明，较高的人工甜味剂摄入量（尤其是甜素、乙酰磺胺酸钾和三氯蔗糖）与心血管疾病风险增加之间存在潜在的直接关联。人工甜味剂存在于全球数千个食品和饮料品牌中，但它们仍然是一个有争议的话题，目前正在由欧洲食品安全局，世界卫生组织和其他卫生机构重新评估。ClinicalTrials.gov www.example.com
To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease). Population based prospective cohort study (2009-21). France, primary prevention research. 103 388 participants of the web based NutriNet-Santé cohort (mean age 42.2±14.4, 79.8% female, 904 206 person years). Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24 h dietary records, including brand names of industrial products. Associations between sweeteners (coded as a continuous variable, log10 transformed) and cardiovascular disease risk, assessed by multivariable adjusted Cox hazard models. Total artificial sweetener intake was associated with increased risk of cardiovascular diseases (1502 events, hazard ratio 1.09, 95% confidence interval 1.01 to 1.18, P=0.03); absolute incidence rate in higher consumers (above the sex specific median) and non-consumers was 346 and 314 per 100 000 person years, respectively. Artificial sweeteners were more particularly associated with cerebrovascular disease risk (777 events, 1.18, 1.06 to 1.31, P=0.002; incidence rates 195 and 150 per 100 000 person years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (1.17, 1.03 to 1.33, P=0.02; incidence rates 186 and 151 per 100 000 person years in higher and non-consumers, respectively), and acesulfame potassium and sucralose were associated with increased coronary heart disease risk (730 events; acesulfame potassium: 1.40, 1.06 to 1.84, P=0.02; incidence rates 167 and 164; sucralose: 1.31, 1.00 to 1.71, P=0.05; incidence rates 271 and 161). The findings from this large scale prospective cohort study suggest a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased cardiovascular disease risk. Artificial sweeteners are present in thousands of food and beverage brands worldwide, however they remain a controversial topic and are currently being re-evaluated by the European Food Safety Authority, the World Health Organization, and other health agencies. ClinicalTrials.gov NCT03335644
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影响因子：
5.4
作者：
Ebbeling CB;Feldman HA;Steltz SK;Quinn NL;Robinson LM;Ludwig DS
通讯作者：
Ludwig DS
影响因子：
6.3
作者：
Andreeva, Valentina A.;Salanave, Benoit;Hercberg, Serge
通讯作者：
Hercberg, Serge
影响因子：
3.9
作者：
Fagherazzi, Guy;Gusto, Gaelle;Boutron-Ruault, Marie-Christine
通讯作者：
Boutron-Ruault, Marie-Christine
影响因子：
4.6
作者：
Chazelas E;Druesne-Pecollo N;Esseddik Y;de Edelenyi FS;Agaesse C;De Sa A;Lutchia R;Rebouillat P;Srour B;Debras C;Wendeu-Foyet G;Huybrechts I;Pierre F;Coumoul X;Julia C;Kesse-Guyot E;Allès B;Galan P;Hercberg S;Deschasaux-Tanguy M;Touvier M
通讯作者：
Touvier M
DOI：
10.1016/s1098-3597(07)80025-1
发表时间：
2007-01-01
期刊：
Clinical cornerstone
影响因子：
--
作者：
Cannon, Christopher P
通讯作者：
Cannon, Christopher P