Infancy weight gain and neurodevelopmental outcomes among term-born infants at age one year: A large prospective cohort study in China.
Infancy weight gain and neurodevelopmental outcomes among term-born infants at age one year: A large prospective cohort study in China.
复制标题
一岁时足月出生婴儿的婴儿期体重增加和神经发育结果：中国的一项大型前瞻性队列研究。
DOI：
10.1080/09297049.2021.1999402
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发表时间：
2021
影响因子：
2.2
通讯作者：
Qiu Xiu
中科院分区：
文献类型：
--
作者：
Lu Min-Shan;Lu Jin-Hua;Zhang Li-Fang;Liu Xian;Zhao Xuan;Nagraj Shobhana;Shen Song-Ying;Xiao Wan-Qing;He Jian-Rong;Qiu Xiu
探讨婴儿期体重增加与足月儿神经发育的关系。单胎足月出生婴儿（n = 5837）来自广州出生队列研究。通过计算从出生到正好12个月的体重差异获得绝对体重增加。主要结局是1岁时的神经发育，包括5个发育领域。总体发育迟缓定义为≥3个领域的发育迟缓。采用多变量逻辑回归分析婴儿期体重增加与神经发育之间的关系。与增重6001-7000 g的婴儿（参考组）相比，增重≤5000 g的婴儿在适应性、粗大运动、精细运动、社交和整体发育延迟方面的延迟几率更高，增重5001-6000 g的婴儿在粗大运动延迟和社交延迟方面的几率更高。性别分层分析显示，与参考组相比，增重≤5000 g与男婴精细运动延迟的几率较高相关，而增重>7000 g与女婴精细运动延迟的几率较高相关。婴儿期体重增加不足与足月出生婴儿一岁时神经发育不良的几率较高有关。
To investigate the association between infancy weight gain and neurodevelopment among term-born infants. Singleton term-born infants (n = 5837) were included from the Born in Guangzhou Cohort Study. Absolute weight gain was obtained by calculating the weight difference from birth to exactly 12 months. The primary outcome was neurodevelopment at age one year, which included five developmental domains. Global developmental delay was defined as delays in ≥3 domains. Multivariable logistic regression was used to examine the associations between infancy weight gain and neurodevelopment. Compared with infants gaining 6001–7000 g (reference group), infants gaining ≤5000 g had higher odds of delay in adaptive, gross motor, fine motor, social, and global developmental delay, infants gaining 5001–6000 g had higher odds of gross motor delay and social delay. A sex-stratified analysis showed that compared with the reference group, gaining ≤5000 g was associated with higher odds of fine motor delay in male infants, while gaining >7000 g was associated with higher odds of fine motor delay in females. Inadequate infancy weight gain is associated with higher odds of poor neurodevelopment at age one year among term-born infants.