Effects of aging on food intake and body composition in rats
Effects of aging on food intake and body composition in rats
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DOI：
10.1016/s0031-9384(02)00800-4
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发表时间：
2002-08-01
影响因子：
2.9
通讯作者：
Corwin, RL
中科院分区：
文献类型：
--
作者：
Thomas, MA;Rice, HB;Corwin, RL
当可选的膳食食物可用时，调节能量摄入的能力的改变可能会导致与年龄相关的身体成分变化。然而，摄食行为尚未在衰老模型中得到广泛研究。本研究采用青年、中年和老年大鼠，在几种不同的可选脂肪可用性方案下检查食物摄入。在整个6周研究期间，为所有大鼠连续提供营养全面的饮食。此外，每个年龄段内的不同亚组可以在控制访问频率的时间表下访问可选的植物起酥油来源：对照（C）-无起酥油访问; MWF-周一，周三和周五2-h起酥油访问; D2-每天2-h起酥油访问; D24-每天24-h起酥油访问。能量摄入量显着更大的组更频繁地获得缩短，无论年龄。然而，大鼠保持过度吞噬的时间长度随着年龄的增长而增加。D24组中老年大鼠体重明显增加，而青年大鼠体重无明显增加。总体脂也显着较高的中年和老年组更频繁地获得缩短，但不是在年轻的大鼠。最后，在D24饮食的老年大鼠中，体灰质量显著降低。这些结果表明，对可选的膳食脂肪来源的反应的改变可能有助于与衰老相关的体脂增加和体内矿物质损失。(C)2002年爱思唯尔科学公司All rights reserved.
Alterations in the ability to adjust energy intake when optional dietary foods are available may contribute to aging-related changes in body composition. Ingestive behavior, however, has not been extensively studied in aging models. The present research used young, middle-aged and old rats to examine food intake under several different schedules of optional fat availability. All rats were provided with continuous access to a nutritionally complete diet throughout the 6-week study. In addition, different subgroups within each age had access to an optional source of vegetable shortening under schedules in which the frequency of access was manipulated: controls (C)-no shortening access; MWF-2-h shortening access on Monday, Wednesday and Friday; D2-2-h shortening access every day; D24-24-h shortening access every day. Energy intake was significantly greater in groups with more frequent access to shortening regardless of age. The length of time the rats remained hyperphagic, however, increased with age. Body weight increased significantly in the D24 group in middle-aged and old rats, but not in young rats. Total body fat was also significantly higher in middle-aged and old groups with more frequent access to shortening, but not in young rats. Finally, body ash mass was significantly reduced in old rats on the D24 diet. These results suggest that alterations in responses to an optional source of dietary fat may contribute to aging-associated body fat accretion and body mineral loss. (C) 2002 Elsevier Science Inc. All rights reserved.