Regulation of mammalian ryanodine receptors
Regulation of mammalian ryanodine receptors
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DOI：
10.2741/meissner
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发表时间：
2002-11-01
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影响因子：
--
通讯作者：
Meissner, G
中科院分区：
文献类型：
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作者：
Meissner, G
Ryanodine受体（RyRs）是大的、高电导的Ca 2+通道，其通过从细胞内隔室（肌/内质网）释放Ca 2+来控制细胞内Ca 2+的水平。哺乳动物组织表达3种密切相关的兰尼碱受体（RyR），称为骨骼肌（RyR 1）、心肌（RyR 2）和脑（RyR 3）。RyR分离为30 S蛋白复合物，由4个560 kDa RyR 2亚基和4个12.6 kDa FK 506结合蛋白（FKBP 12.6）亚基组成。多种内源性效应分子和翻译后修饰调节RyRs。本章综述了内源性效应分子对哺乳动物RyRs的调控。
Ryanodine receptors (RyRs) are large, high conductance Ca2+ channels that control the level of intracellular Ca2+ by releasing Ca2+ from an intracellular compartment, the sarco/endoplasmic reticulum. Mammalian tissues express 3 closely related ryanodine receptors (RyRs) known as skeletal muscle (RyR1), cardiac muscle (RyR2) and brain (RyR3). The RyRs are isolated as 30S protein complexes comprised of four 560 kDa RyR2 subunits and four 12.6 kDa FK506 binding protein (FKBP12.6) subunits. Multiple endogenous effector molecules and posttranslational modifications regulate the RyRs. This chapter reviews the regulation of the mammalian RyRs by endogenous effector molecules.