Phylogeny and Biotransformation. Part 5*: Biotransformation of Isopinocampheol
Phylogeny and Biotransformation. Part 5*: Biotransformation of Isopinocampheol
复制标题
系统发育和生物转化。
DOI：
10.1515/znc-1994-9-1004
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
W. Abraham
中科院分区：
文献类型：
--
作者：
W. Abraham
用100株细菌和真菌对异松苯丙胺进行生物转化，除得到3个重排单萜外，还得到1-、2-、4-、5-、7-、8 -和9-羟基异松苯丙胺，其中一个重排单萜具有新的异癸烷骨架。观察到（+）-和（-）-异松苯丙胺之间的明显的对映选择性。各个菌株的系统发育位置可以从它们形成（+）-异松苯丙胺产物的能力中看出。1，3-二羟基蒎烷的形成是细菌的领域，而3，5-或3，7-二羟基蒎烷主要由真菌，特别是接合菌亚门的真菌形成。担子菌亚门对异松苯丙胺的氧化活性较低。这些信息可以用于更有效地选择用于筛选的菌株。
Abstract Biotransformation of isopinocampheol with 100 bacterial and fungal strains yielded 1-, 2-, 4-, 5-, 7-, 8 - and 9-hydroxy-isopinocampheol besides three rearranged monoterpenes, one of them bearing the novel isocarane skeleton. A pronounced enantioselectivity between (+)- and (-)-isopinocampheol was observed. The phylogenetic position of the individual strains could be seen in their ability to form the products from (+)-isopinocampheol. The formation of 1,3-dihydroxypinane is a domain of bacteria, while 3,5- or 3,7-dihydroxypinane was mainly formed by fungi, especially those of the phylum Zygomycotina. The activity of Basidiomycotina towards oxidation of isopinocampheol was rather low. Such informations can be used in a more effective selection of strains for screening.