Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients.
Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients.
复制标题
免疫功能低下/肿瘤患者侵袭性真菌感染的血液诊断。
DOI：
10.1097/inf.0000000000000797
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
W. Steinbach
中科院分区：
文献类型：
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作者：
W. Steinbach
早期、准确的诊断是改善儿童侵袭性真菌感染预后的基石。由于血液培养对念珠菌的敏感性估计约为50%，并且支气管肺泡灌洗培养物中曲霉生长的可能性更低，因此更新的分子真菌生物标志物对于实现总体临床目标至关重要。通常，有侵袭性真菌感染风险的患者足够脆弱，因此基于血液的策略是唯一可以安全使用的策略。这篇简短的综述将重点介绍免疫功能低下儿童血液真菌生物标志物的最新进展和想法（表1）。
T cornerstone to improving outcomes in invasive fungal infections in children is early, accurate diagnosis. With the sensitivity of blood culture for candidemia estimated to be approximately 50%, and the likelihood of Aspergillus growing in culture from bronchoalveolar lavage even worse, newer molecular fungal biomarkers are paramount to achieving that overall clinical goal. Often the patients at risk for invasive fungal infections are fragile enough that a blood-based strategy is all that can be safely employed. This brief review will highlight newer developments and thoughts focused only on blood-based fungal biomarkers for immunocompromised children (Table 1).