Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets.
Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets.
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DOI：
10.1371/journal.pone.0027512
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Kelvin AA
中科院分区：
文献类型：
--
作者：
Huang SS;Banner D;Fang Y;Ng DC;Kanagasabai T;Kelvin DJ;Kelvin AA
甲型和B型流感感染是人类和动物的全球性健康问题。流感病毒的高遗传进化率使得新毒株不断出现，并导致疾病变异。由于人类流感感染通常会因次要因素（如年龄和基础医疗状况）而复杂化，因此很难评估毒株或亚型特异性临床特征。在这里，我们用13种目前流行的流感病毒株（包括2009年大流行H1 N1 [H1 N1 pdm]和季节性A/H1 N1、A/H3 N2和B病毒株）感染雪貂。在稳定的环境条件下每天测量临床参数，持续14天，以比较临床特征。我们发现，H1N1 pdm毒株比全季节毒株具有更严重的生理影响，其中大流行A/加州/07/2009是最具临床致病性的大流行毒株。季节性A/H1 N1和A/H3 N2群体中最严重的疾病分别由A/所罗门群岛/03/2006和A/珀斯/16/2009引起。在13株研究菌株中，B/Hubei-Wujiagang/158/2009的临床症状最轻。我们还发现，疾病的严重程度（通过临床疾病和组织病理学）与流感特异性抗体反应相关，但与上呼吸道中的病毒复制无关。H1N1 pdm诱导的抗体应答最高和最快，其次是季节性A/H3 N2、季节性A/H1N1和季节性流感B（B/Hubei-Wujiagang/158/2009诱导的应答最弱）。我们的研究是第一次比较雪貂中多种流行流感病毒株的临床特征。这些发现将有助于描述特定流感病毒株的临床特征，并深入了解适当流感治疗药物的开发和管理。
Influenza A and B infections are a worldwide health concern to both humans and animals. High genetic evolution rates of the influenza virus allow the constant emergence of new strains and cause illness variation. Since human influenza infections are often complicated by secondary factors such as age and underlying medical conditions, strain or subtype specific clinical features are difficult to assess. Here we infected ferrets with 13 currently circulating influenza strains (including strains of pandemic 2009 H1N1 [H1N1pdm] and seasonal A/H1N1, A/H3N2, and B viruses). The clinical parameters were measured daily for 14 days in stable environmental conditions to compare clinical characteristics. We found that H1N1pdm strains had a more severe physiological impact than all season strains where pandemic A/California/07/2009 was the most clinically pathogenic pandemic strain. The most serious illness among seasonal A/H1N1 and A/H3N2 groups was caused by A/Solomon Islands/03/2006 and A/Perth/16/2009, respectively. Among the 13 studied strains, B/Hubei-Wujiagang/158/2009 presented the mildest clinical symptoms. We have also discovered that disease severity (by clinical illness and histopathology) correlated with influenza specific antibody response but not viral replication in the upper respiratory tract. H1N1pdm induced the highest and most rapid antibody response followed by seasonal A/H3N2, seasonal A/H1N1 and seasonal influenza B (with B/Hubei-Wujiagang/158/2009 inducing the weakest response). Our study is the first to compare the clinical features of multiple circulating influenza strains in ferrets. These findings will help to characterize the clinical pictures of specific influenza strains as well as give insights into the development and administration of appropriate influenza therapeutics.
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影响因子：
3.7
作者：
Rowe T;León AJ;Crevar CJ;Carter DM;Xu L;Ran L;Fang Y;Cameron CM;Cameron MJ;Banner D;Ng DC;Ran R;Weirback HK;Wiley CA;Kelvin DJ;Ross TM
通讯作者：
Ross TM
影响因子：
6.7
作者：
Hamelin ME;Baz M;Abed Y;Couture C;Joubert P;Beaulieu E;Bellerose N;Plante M;Mallett C;Schumer G;Kobinger GP;Boivin G
通讯作者：
Boivin G
大流行（H1N1）2009流感。
影响因子：
9.8
作者：
Patel M;Dennis A;Flutter C;Khan Z
通讯作者：
Khan Z
影响因子：
14.6
作者：
O'Riordan, Sean;Barton, Michelle;Tran, Dat
通讯作者：
Tran, Dat
影响因子：
5.4
作者：
Fang, Yuan;Rowe, Thomas;Kelvin, David J.
通讯作者：
Kelvin, David J.