REVERSAL OF D-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE
REVERSAL OF D-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE
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DOI：
10.1128/jb.84.1.154-156.1962
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发表时间：
1962-01-01
影响因子：
3.2
通讯作者：
ZYGMUNT, WA
中科院分区：
文献类型：
--
作者：
ZYGMUNT, WA
在化学成分确定的培养基上活跃生长的细菌培养物中，丙氨酸对 D-4-氨基-3-异恶唑烷酮抗菌活性的逆转在需要外源丙氨酸的培养物和能够合成丙氨酸的培养物中进行了比较。 DL-丙氨酸是酿酒片球菌中最有效的逆转剂。 D-丙氨酸是一种需要丙氨酸的生物体，D-丙氨酸对合成丙氨酸的生物体大肠杆菌和金黄色葡萄球菌有效。对于所有三种培养物，L-丙氨酸是效果最差的逆转剂。
Reversal of the antibacterial activity of D-4-amino-3-isoxazolidone by alanine in bacterial cultures actively growing on chemically defined media was compared in cultures requiring exogenous alanine and those capable of its synthesis. DL-Alanine was the most effective reversal agent in Pediococcus cerevisiae. an alanine-requiring organism, and D-ala-nine was effective in Escherichia coli and Staphylococcus aureus, organisms synthesizing alanine. With all three cultures, L-alanine was the least effective reversal agent.