Mitochondria and Iron: current questions.
Mitochondria and Iron: current questions.
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DOI：
10.1080/17474086.2016.1268047
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发表时间：
2017-01
影响因子：
2.8
通讯作者：
Torti SV
中科院分区：
文献类型：
--
作者：
Paul BT;Manz DH;Torti FM;Torti SV
线粒体是细胞器，执行许多生物能量，生物合成和调节功能，并在铁代谢中发挥核心作用。细胞外铁被细胞吸收并转运到线粒体，在线粒体中用于合成参与氧化还原反应、DNA合成和修复以及各种其他细胞过程的酶的功能所必需的辅因子。本文综述了铁向线粒体的运输和正常的线粒体铁代谢，包括血红素合成和铁硫簇生物合成。我们对线粒体铁代谢的大部分理解已经被破坏正常铁代谢的病理学所揭示。这些疾病不仅影响铁代谢，还影响线粒体功能和全身健康。因此，本文还讨论了这些病理，包括全身和线粒体铁失调以及癌症的条件。通过PubMed检索，使用关键词：铁、线粒体、血红素合成、铁硫簇和癌症，识别了涵盖这些领域的文献。还查阅了使用该检索策略检索到的出版物引用的参考文献。虽然对线粒体铁的了解很多，但关键问题仍然存在。更好地了解线粒体铁调节将是开发影响线粒体铁的综合征的治疗方法的关键。
Mitochondria are cellular organelles that perform numerous bioenergetic, biosynthetic, and regulatory functions and play a central role in iron metabolism. Extracellular iron is taken up by cells and transported to the mitochondria, where it is utilized for synthesis of cofactors essential to the function of enzymes involved in oxidation-reduction reactions, DNA synthesis and repair, and a variety of other cellular processes. This article reviews the trafficking of iron to the mitochondria and normal mitochondrial iron metabolism, including heme synthesis and iron-sulfur cluster biogenesis. Much of our understanding of mitochondrial iron metabolism has been revealed by pathologies that disrupt normal iron metabolism. These conditions affect not only iron metabolism but mitochondrial function and systemic health. Therefore, this article also discusses these pathologies, including conditions of systemic and mitochondrial iron dysregulation as well as cancer. Literature covering these areas was identified via PubMed searches using keywords: Iron, mitochondria, Heme Synthesis, Iron-sulfur Cluster, and Cancer. References cited by publications retrieved using this search strategy were also consulted. While much has been learned about mitochondrial iron, key questions remain. Developing a better understanding of mitochondrial iron regulation will be paramount in developing therapies for syndromes that affect mitochondrial iron.
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影响因子：
4.8
作者：
Cai, Kai;Frederick, Ronnie O.;Markley, John L.
通讯作者：
Markley, John L.
影响因子：
20.3
作者：
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通讯作者：
Mootha, Vamsi K.
影响因子：
4.2
作者：
Carroll, C. B.;Zeissler, M. -L.;Hanemann, C. O.
通讯作者：
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