Deaminative and decarboxylative catalytic alkylation of amino acids with ketones.
Deaminative and decarboxylative catalytic alkylation of amino acids with ketones.
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DOI：
10.1002/anie.201307766
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发表时间：
2013-12
影响因子：
--
通讯作者：
N. Kalutharage;Chae S. Yi
中科院分区：
文献类型：
--
作者：
N. Kalutharage;Chae S. Yi
它有两种方式：阳离子[Ru-H]络合物催化α-和β-氨基酸与酮的选择性偶联，形成α-烷基化酮产物。该反应涉及C = C和C = N键裂解，其导致使用氨基酸的区域和立体选择性烷基化。一个广泛的基板范围和高功能组的公差被证明。
It cuts two ways: The cationic [Ru-H] complex catalyzes selective coupling of α- and β-amino acids with ketones to form α-alkylated ketone products. The reaction involves CC and CN bond cleavage which result in regio- and stereoselective alkylation using amino acids. A broad substrate scope and high functional-group tolerance is demonstrated.