Association between meibomian gland changes and aging, sex, or tear function
Association between meibomian gland changes and aging, sex, or tear function
复制标题
DOI：
10.1097/01.ico.0000227889.11500.6f
复制
发表时间：
2006-07-01
期刊：
影响因子：
2.8
通讯作者：
Shimazaki, Jun
中科院分区：
文献类型：
--
作者：
Den, Seika;Shimizu, Kazuhiro;Shimazaki, Jun
目的：研究眼睑边缘和睑板腺的变化及其与年龄、性别和泪液功能的关系。方法：我们检查了177名无眼部症状或眼表疾病的受试者（76名男性，101名女性，21-93岁，平均年龄63.0±14.3岁）的354只眼睛。应用裂隙灯生物显微镜观察眼睑边缘的解剖变化。分别根据meibum表达和meibography评价meibomi腺功能和形态学。采用Schirmer试验、泪膜破裂时间和荧光素染色试验评估泪液功能和眼表上皮。结果：眼睑缘解剖异常26眼（7.3%）、睑脂分泌减少46眼（12.4%）、睑脂腺脱落68眼（18.6%），与年龄有显著相关性（P值分别< 0.0001、0.0498、< 0.0001）。在69岁的患者中，睑板腺相关的发现与性别之间没有明显的关联。然而，与女性相比，男性bb0 = 70岁的眼睑边缘异常和腺体脱落的发生率较高。在>= 40岁的患者中，眼睑边缘和睑板腺的变化与撕裂功能之间没有明显的关联。结论：在无症状的受试者中，我们发现眼睑边缘和睑板腺的变化与衰老密切相关。在老年受试者中，解剖学上眼睑边缘和睑板腺形态的变化在男性中比在女性中更常见。撕裂功能与眼睑边缘或睑板腺功能的改变均无关联。
Purpose: To study changes in the lid margin and meibomian glands and their association with aging, sex, and tear function.Methods: We examined 354 eyes in 177 subjects (76 men and 101 women; 21-93 years; mean age, 63.0 +/- 14.3 years) with no ocular symptoms or ocular surface disorders. Anatomic changes in the lid margin were studied using slit-lamp biomicroscopy. Meibomian gland function and morphology were evaluated on the basis of meibum expression and meibography, respectively. Tear function and ocular surface epithelium were assessed with the Schirmer test, by tear film break-up time, and with a fluorescein staining test.Results: Eyes with abnormal lid margin anatomy, hyposecretion of meibum, and meibomian gland dropout were seen in 26 (7.3%), 46 (12.4%), and 68 eyes (18.6%), respectively, with a significant association between each finding and aging (P = < 0.0001, 0.0498, and < 0.0001, respectively). In patients : 69 years of age, no significant association was found between meibomian gland-related findings and sex. However, a high incidence of abnormal lid margin and gland dropout was noted in men >= 70 years of age compared with women. No significant association was found between changes in the lid margin and meibomian glands and tear function in patients >= 40 years of age.Conclusion: Among symptom-free subjects, we found that changes in the lid margin and meibomian glands were closely related to aging. Among elderly subjects, changes in the anatomic lid margin and meibomian gland morphology were observed more frequently in men than in women. Tear function showed no association with either changes in the lid margin or function of the meibomian glands.