Therapeutic strategies in inflammasome mediated diseases of the liver.
Therapeutic strategies in inflammasome mediated diseases of the liver.
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DOI：
10.1016/j.jhep.2012.12.017
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发表时间：
2013-05
影响因子：
25.7
通讯作者：
Mehal, Wajahat
中科院分区：
文献类型：
--
作者：
Hoque, Rafaz;Vodovotz, Yoram;Mehal, Wajahat
即使在没有病原体的情况下，组织应力和细胞死亡也会导致炎症。这种无菌性炎症依赖于免疫细胞内的蛋白质的胞质复合物，称为炎性体。该复合物通过激活caspase-1和分泌IL-1β和IL-18将两组细胞外信号转化为炎症反应。组1信号通常是TOLL样受体激动剂，并导致炎性体组分和前细胞因子的转录上调。第2组信号是多样的，从尿酸到ATP，并导致炎症体复合物的组装和活化。炎症体组分是广泛的急性和慢性病理所必需的，包括实验性酒精性和非酒精性脂肪性肝炎以及药物诱导的肝损伤。总的来说，组1和组2信号、炎性体组分和细胞因子受体提供了丰富的治疗靶点来源。该领域的许多进展都来自标准的还原论实验。然而，对复杂人类系统的理解的进展将取决于新的策略，如系统分析，分析大型数据集以提供新的见解。
Tissue stress and cell death result in inflammation even in the absence of pathogens. Such sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells termed the inflammasome. This complex converts two groups of extracellular signals into an inflammatory response via activation of caspase-1 and secretion of IL-1β and IL-18. Group 1 signals are typically TOLL like receptor agonists and result in transcriptional upregulation of inflammasome components and pro-cytokines. Group 2 signals are diverse, ranging from uric acid to ATP, and lead to assembly and activation of the inflammasome complex. Inflammasome components are required for a wide range of acute and chronic pathologies, including experimental alcoholic and non-alcoholic steatohepatitis, and drug-induced liver injury. Collectively, group 1 and 2 signals, inflammasome components, and cytokine receptors provide a rich source of therapeutic targets. Many of the advances in the field have come from standard reductionist experiments. Progress in the understanding of complex human systems will, however, be dependent on novel strategies such as systems analysis, which analyze large data sets to provide new insights.
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影响因子：
29.4
作者：
Miura K;Kodama Y;Inokuchi S;Schnabl B;Aoyama T;Ohnishi H;Olefsky JM;Brenner DA;Seki E
通讯作者：
Seki E
影响因子：
13.5
作者：
Bamboat, Zubin M.;Balachandran, Vinod P.;Ocuin, Lee M.;Obaid, Hebroon;Plitas, George;DeMatteo, Ronald P.
通讯作者：
DeMatteo, Ronald P.
DOI：
10.1053/j.jvca.2008.08.005
发表时间：
2009-06-01
影响因子：
2.8
作者：
Bennett-Guerrero, Elliott;Swaminathan, Madhav;Fink, Mitchell P.
通讯作者：
Fink, Mitchell P.
影响因子：
4.3
作者：
An GC;Faeder JR
通讯作者：
Faeder JR
DOI：
10.1002/art.24209
发表时间：
2008-11-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Schumacher, H. Ralph, Jr.;Becker, Michael A.;Joseph-Ridge, Nancy
通讯作者：
Joseph-Ridge, Nancy