GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables
GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables
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DOI：
10.1016/j.jclinepi.2019.12.021
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发表时间：
2020-06-01
影响因子：
7.2
通讯作者：
Guyatt, Gordon H.
中科院分区：
文献类型：
--
作者：
Schunemann, Holger J.;Mustafa, Reem A.;Guyatt, Gordon H.
目的：本文提供了更新的GRADE指南，介绍了系统综述和卫生技术评估的作者以及指南制定者如何对一系列证据的证据确定性（也称为证据质量或估计置信度）进行评级，这些证据涉及领域不精确性，不一致性，出版偏倚和其他领域的测试准确性（TA）。它还为如何在证据概况和结果汇总表中呈现综合信息提供了指导。研究设计和设置：我们提出了临床和公共卫生中TA确定性评级指南，并回顾了有关测试的大量证据结果的呈现。通过实际例子的补充，我们描述了证据的评级者如何应用GRADE域的不一致性，不精确性，结论：在科克伦和其他综述以及世界卫生组织和其他指南中使用GRADE有助于改进GRADE方法对TA研究证据的确定性进行评级。虽然几个GRADE域（例如，虽然这些结论（不精确性和关联程度）需要进一步的方法学研究，以帮助将其付诸实施，但需要在迄今已知的基础上作出判断。(C)2020爱思唯尔公司All rights reserved.
Objectives: This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments and guideline developers can rate the certainty of evidence (also known as quality of the evidence or confidence in the estimates) of a body of evidence addressing test accuracy (TA) on the domains imprecision, inconsistency, publication bias, and other domains. It also provides guidance for how to present synthesized information in evidence profiles and summary of findings tables.Study Design and Setting: We present guidance for rating certainty in TA in clinical and public health and review the presentation of results of a body of evidence regarding tests.Results: Supplemented by practical examples, we describe how raters of the evidence can apply the GRADE domains inconsistency, imprecision, and publication bias to a body of evidence of TA studies.Conclusion: Using GRADE in Cochrane and other reviews as well as World Health Organization and other guidelines helped refining the GRADE approach for rating the certainty of a body of evidence from TA studies. Although several of the GRADE domains (e.g., imprecision and magnitude of the association) require further methodological research to help operationalize them, judgments need to be made on the basis of what is known so far. (C) 2020 Elsevier Inc. All rights reserved.