Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection.
Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection.
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DOI：
10.1016/j.neuron.2015.05.038
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
McCormick DA
中科院分区：
文献类型：
--
作者：
McGinley MJ;David SV;McCormick DA
信号检测任务性能的最佳状态的神经相关性在很大程度上是未知的。一种假说认为，最佳状态表现出紧张性去极化皮层神经元增强尖峰活动，如在运动过程中发生。我们记录了小鼠听觉皮层神经元的膜电位，这些小鼠接受了具有挑战性的噪声中的音调检测任务的训练，同时用瞳孔测量和海马记录来评估唤醒。唤醒措施准确地预测多种模式的膜电位活动，包括：在低唤醒的节奏缓慢的振荡，稳定的超极化在中间唤醒，和去极化阶段或紧张时期的超唤醒。走路总是发生在过度兴奋的时候。最佳的信号检测行为和声音诱发的反应，在阈下和尖峰水平，发生在中间觉醒时，前决策膜电位稳定超极化。这些结果揭示了经典观察到的任务性能和唤醒之间的倒U型关系的皮质生理特征，并且最佳检测表现出增强的感觉诱发反应和减少的背景突触活动。
The neural correlates of optimal states for signal detection task performance are largely unknown. One hypothesis holds that optimal states exhibit tonically depolarized cortical neurons with enhanced spiking activity, such as occur during movement. We recorded membrane potentials of auditory cortical neurons in mice trained on a challenging tone-in-noise detection task while assessing arousal with simultaneous pupillometry and hippocampal recordings. Arousal measures accurately predicted multiple modes of membrane potential activity, including: rhythmic slow oscillations at low arousal, stable hyperpolarization at intermediate arousal, and depolarization during phasic or tonic periods of hyper-arousal. Walking always occurred during hyper-arousal. Optimal signal detection behavior and sound-evoked responses, at both sub-threshold and spiking levels, occurred at intermediate arousal when pre-decision membrane potentials were stably hyperpolarized. These results reveal a cortical physiological signature of the classically-observed inverted-U relationship between task performance and arousal, and that optimal detection exhibits enhanced sensory-evoked responses and reduced background synaptic activity.