The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
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DOI：
10.4161/cc.8.2.7356
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发表时间：
2009-01-15
期刊：
影响因子：
4.3
通讯作者：
Hoppe, Thorsten
中科院分区：
文献类型：
--
作者：
Deichsel, Alexandra;Mouysset, Julien;Hoppe, Thorsten
基因组的有效复制及其在两个子细胞中的平均分布是所有分裂生物体的基本过程。为了确保DNA复制在细胞周期的S期仅发生一次，复制的起始受到严格控制。起始因子负责将复制体（执行DNA合成的大型分子机器）募集到复制起点并许可它们开始DNA复制。值得注意的是，大多数目前已知的引发剂已被归类为AAA（+）ATP酶家族的成员。1在我们最近的研究中，我们确定了一个额外的AAA+ ATP酶，CDC-48，是秀丽隐杆线虫中正确DNA复制所必需的。2在这里，我们推测CDC-48（在酵母中也称为Cdc 48 p，在脊椎动物中也称为p97）在DNA复制起始过程中的功能，解决其泛素选择性伴侣活性。
Efficient duplication of the genome and its equal distribution into both daughter cells is an essential process for all dividing organisms. To ensure that DNA replication occurs only once during the S phase of the cell cycle, initiation of replication is tightly controlled. Initiation factors are responsible for the recruitment of the replisome, the large molecular machine carrying out DNA synthesis, to origins of replication and license them to start DNA duplication. Remarkably, most of the currently known initiators have been classified as members of the family of AAA(+) ATPases. 1 In our recent study we identified an additional AAA+ ATPase, CDC-48, to be essential for proper DNA replication in Caenorhabditis elegans. 2 Here, we speculate on the function of CDC-48 (also known as Cdc48p in yeast and p97 in vertebrates) during DNA replication initiation, addressing its ubiquitin-selective chaperone activity.