The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges
The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges
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DOI：
10.1101/cshperspect.a011544
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发表时间：
2012-10-01
影响因子：
7.2
通讯作者：
Lorsch, Jon R.
中科院分区：
文献类型：
--
作者：
Hinnebusch, Alan G.;Lorsch, Jon R.
翻译起始在真核生物中是一个高度调控和复杂的基因表达阶段。它需要至少12个起始因子的作用，其中许多已知是调控途径的目标。在这里，我们回顾了我们目前对真核生物翻译起始的分子力学的理解，重点介绍了体外和体内研究的最新突破。我们还确定了需要新想法和新技术来解决的未解决的重要问题。
Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.