PARKINSONS-DISEASE AND DEPRESSION - A CRITICAL REEVALUATION
PARKINSONS-DISEASE AND DEPRESSION - A CRITICAL REEVALUATION
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DOI：
10.1093/brain/109.2.279
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发表时间：
1986-04-01
期刊：
影响因子：
14.5
通讯作者：
KENNY, FT
中科院分区：
文献类型：
--
作者：
TAYLOR, AE;SAINTCYR, JA;KENNY, FT
帕金森病（PD）病理生理学固有的“有机”抑郁的可能性，可与内源性抑郁（重度抑郁发作）相媲美。也有人认为，PD患者的抑郁症状仅仅是患者对其进行性和不可避免的身体限制和独立功能丧失的自然反应，因为传统的抑郁评定量表范围有限，因此我们对PD患者的抑郁进行了心理测量学调查。基于内源性抑郁症中已知的短期记忆（STM）障碍，本研究在一组精神患者中得到了证实。对PD抑郁组、非抑郁组及15例正常对照进行STM测定。不管抑郁症的严重程度如何，PD患者的表现与对照组一样好，且两组的得分均显著高于内源性抑郁患者。PD患者在顺序依赖性STM测试中的相对弱势被进一步探讨，并被解释为轻度额叶功能障碍的迹象。结论是PD患者在面对行为限制时经常抑郁，这种反应可能被一种情绪障碍加剧不稳定性与可能涉及前额皮质区的病理生理过程有关。
The possibility of an ‘organically’ based depression intrinsic to the pathophysiology of Parkinson's disease (PD) and comparable to endogenous depression (Major Depressive Episode) has been raised. It has also been argued that signs of depression observed in PD are merely the natural reaction of the patients to their progressive and inevitable physical limitations and loss of independent function Because conventional depression rating scales are limited in scope, a psychometric investigation of depression in PD was pursuedBased on the known impairment of short-term memory (STM) in endogenous depression, which was confirmed in a group of psychiatric patients in the present study, measures of STM were also obtained in groups of depressed and nondepressed PD patients and in 15 normal control subjects.Regardless of depression severity, PD patients performed as well as control subjects and both these groups consistently obtained scores significantly better than those of the endogenously depressed patients A relative weakness in the PD patients on order-dependent STM tests was further explored and interpreted as an indication of mild frontal lobe dysfunctionIt was concluded that PD patients are frequently depressed when confronted with their behavioural limitations and that this reaction may be exacerbated by a form of emotional lability related to pathophysiological processes which may involve prefrontal cortical areas.