Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations.
Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations.
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DOI：
10.1016/s0002-9440(10)63862-x
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发表时间：
2003-02
期刊：
影响因子：
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通讯作者：
A. Tierens;J. Delabie;A. Małecka;Junbai Wang;A. Gruszka-Westwood;D. Catovsky;E. Matutes
中科院分区：
文献类型：
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作者：
A. Tierens;J. Delabie;A. Małecka;Junbai Wang;A. Gruszka-Westwood;D. Catovsky;E. Matutes
脾边缘区淋巴瘤（也称为脾绒毛淋巴细胞淋巴瘤）是一种具有特征性形态和表型的B细胞非霍奇金淋巴瘤。我们研究了23例重排免疫球蛋白重链基因的体细胞超突变模式，并将这些数据与生存以及免疫表型和遗传特征的情况下。三分之二的病例显示免疫球蛋白基因突变，其中一半显示抗原选择的证据，而三分之一的病例显示没有显著的突变。正在进行的突变，滤泡性淋巴瘤的特征性特征，在所有6例随机选择用于本分析的病例中得到证实，包括一例突变数量较少（<2%）的病例。免疫球蛋白突变状态与临床、免疫表型或遗传特征之间无统计学显著相关性。我们的研究结果表明，正在进行的体细胞高突变是一个突出的特点，脾边缘区淋巴瘤循环绒毛淋巴细胞。正在进行的体细胞超突变先前已被证明在结外和结边缘区淋巴瘤。我们的研究结果表明，边缘区淋巴瘤在不同的解剖定位可能来自一个类似的B细胞亚群。
Splenic marginal zone lymphoma (also splenic lymphoma with villous lymphocytes) is a B-cell non-Hodgkin's lymphoma with a characteristic morphology and phenotype. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases show immunoglobulin gene mutations, half of which show evidence of antigen selection, whereas one-third of the cases show no significant mutations. On-going mutation, a feature characteristic of follicular lymphoma, was demonstrated in all six cases randomly selected for this analysis, including one case with a low number of mutations (<2%). No statistical significant correlation was found between immunoglobulin mutation status and clinical, immunophenotypic, or genetic characteristics. Our results demonstrate that on-going somatic hypermutation is a prominent feature of splenic marginal zone lymphoma with circulating villous lymphocytes. On-going somatic hypermutation has previously been demonstrated in extra-nodal and nodal marginal zone lymphoma. Our results indicate that marginal zone lymphomas at different anatomical localizations may derive from a similar B-cell subset.