Chromosomal translocations affecting 12q14-15 but not deletions of the long arm of chromosome 7 associated with a growth advantage of uterine smooth muscle cells
Chromosomal translocations affecting 12q14-15 but not deletions of the long arm of chromosome 7 associated with a growth advantage of uterine smooth muscle cells
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DOI：
10.1093/molehr/5.12.1150
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发表时间：
1999-12-01
影响因子：
4
通讯作者：
Bullerdiek, J
中科院分区：
文献类型：
--
作者：
Hennig, Y;Deichert, U;Bullerdiek, J
子宫平滑肌瘤是细胞遗传学上研究最多的人类肿瘤。最常见的克隆异常是涉及12q14-15的结构重排和7号染色体长臂部分缺失。本研究调查了与具有明显正常核型的肌瘤相比，这些异常可能带来的生长优势。共有155例肌瘤纳入研究。所有的样本都是在子宫切除术后获得的，可以对所有可检测到的肿瘤进行核型分析。染色体克隆异常的肌瘤明显大于核型正常的肌瘤（6.8 +/- 5.3 vs 3.4 +/- 2.1 cm; P < 0.001）。然而，当区分两种主要畸变时，发现影响高迁移率组蛋白IC （HMGIC）基因（8.9 +/- 5.6 cm）的12q14-15变化的肌瘤是正确的，而以7号染色体缺失（3.5 +/- 2.0 cm）为特征的肿瘤组则不是如此。结果与肌瘤是由未知事件引起的假设相一致，而染色体异常是继发性变化，影响HMGIC基因的染色体异常增加了相应肿瘤的生长潜力。
Cytogenetically, uterine leiomyomata are the best investigated human tumours. The most frequent clonal abnormalities are structural rearrangements involving 12q14-15 and deletions of part of the long arm of chromosome 7. The present study investigated a possible growth advantage conferred by these abnormalities, when compared with myomata having an apparently normal karyotype. A total of 155 myomata were included in the study. All samples were obtained after hysterectomy enabling karyotype analysis of all detectable tumours. Myomata with clonal chromosome abnormalities were significantly larger than those with a normal karyotype (6.8 +/- 5.3 versus 3.4 +/- 2.1 cm; P < 0.001). However, when differentiating between the two main aberrations, this was found to be true for the myomata with 12q14-15 changes affecting the high mobility group protein IC (HMGIC) gene (8.9 +/- 5.6 cm), but not for the group of tumours characterized by deletions of chromosome 7 (3.5 +/- 2.0 cm). The results are compatible with the hypothesis that myomata develop due to an unknown event, whereas the chromosomal abnormalities act as secondary changes, with those affecting the HMGIC gene increasing the growth potential of the corresponding tumours.