TRANSPORT OF STEROID-HORMONES - BINDING OF 21 ENDOGENOUS STEROIDS TO BOTH TESTOSTERONE-BINDING GLOBULIN AND CORTICOSTEROID-BINDING GLOBULIN IN HUMAN-PLASMA
TRANSPORT OF STEROID-HORMONES - BINDING OF 21 ENDOGENOUS STEROIDS TO BOTH TESTOSTERONE-BINDING GLOBULIN AND CORTICOSTEROID-BINDING GLOBULIN IN HUMAN-PLASMA
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DOI：
10.1210/jcem-53-1-58
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发表时间：
1981-01-01
影响因子：
5.8
通讯作者：
RODBARD, D
中科院分区：
文献类型：
--
作者：
DUNN, JF;NISULA, BC;RODBARD, D
描述了人血浆中类固醇转运的模型。在平衡条件下，使用固相法在生理 pH 和温度下测定 21 种内源性类固醇对睾酮结合球蛋白 (TeBG) 和皮质类固醇结合球蛋白 (CBG) 的结合亲和力。使用计算机程序来解决这些类固醇与 TeBG、CBG 和白蛋白之间复杂的平衡相互作用。以这种方式，计算了正常男性、卵巢周期的卵泡期和黄体期的正常女性以及正常妊娠第三个月的女性中每种类固醇在TeBG结合、CBG结合、白蛋白结合和未结合部分中的血浆分布。
A model of steroid transport in human plasma is described. The binding affinities of 21 endogenous steroids for both testosterone-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were determined under equilibrium conditions using a solid phase method at physiological pH and temperature. A computer program was used to solve the complex equilibrium interactions between these steroids and TeBG, CBG and albumin. In this manner, the plasma distribution of each steroid into TeBG-bound, CBG-bound, albumin-bound and unbound fractions in normal men, normal women during both the follicular and luteal phases of the ovarian cycle and women during the 3rd trimester of a normal pregnancy was calculated.