Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3 cm or less in diameter
Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3 cm or less in diameter
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DOI：
10.1016/j.ejcts.2006.06.029
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发表时间：
2006-09-01
影响因子：
3.4
通讯作者：
Roh, Mee Sook
中科院分区：
文献类型：
--
作者：
Choi, Phil Jo;Yang, Doo Kyung;Roh, Mee Sook
目的：肌成束蛋白是一种肌动蛋白捆绑蛋白，其诱导细胞膜突起并增加正常和转化上皮细胞的运动性。我们通过免疫组化评估了fascin的表达，以确定其在小尺寸周围型肺腺癌进展中的作用，并阐明其作为术前新治疗选择的实用性。方法：采用免疫组化法对49例周围型腺癌（高级别腺癌占25%）中fascin的表达进行检测。结果：49例中30例（61.2%）呈fascin阳性。Fascin高表达者淋巴结转移（P = 0.0007）、淋巴管浸润（P = 0.0084）和分期（P = 0.05）明显增高。年龄、性别、肿瘤大小及组织学类型与乳腺癌的发生无明显相关性。在本研究中，被认为是经皮穿刺活检样本替代品的2 mm尺寸TMA芯显示出与CWT切片一致的结果（kappa = 0.836）。结论：我们认为，肌成束蛋白免疫反应性可以确定的子集周围腺癌的肺3厘米或更小的直径，有不同的潜力转移到区域淋巴结。评估术前活检样本的fascin免疫反应性可能是一种新的治疗策略，以选择最合适的治疗小尺寸肺腺癌。(c)2006 Elsevier B.V.保留所有权利。
Objective: Fascin is an actin-bundling protein that induces cell membrane protrusions and increases the motility of normal and transformed epithelial cells. We evaluated the expression of fascin by performing immunohistochemistry to determine its role in the progression of small-size peripheral lung adenocarcinomas and to elucidate its utility as a preoperative novel therapeutic option. Methods: Immunohistochemistry for fascin was performed in 49 peripheral adenocarcinomas of 25% (high grade). Results: Overall, fascin immunoreactivity was detected in 30 (61.2%) out of the total 49 cases. The tumors with high-grade fascin immunoreacivity tended to more frequently show lymph node metastasis (P = 0.0007), lymphovascular invasion (P = 0.0084) and a higher stage (P = 0.05). There was no significant association with age, gender, tumor size and the histological subtype. The 2 mm-sized TMA cores, which were considered as a substitute for percutaneous needle biopsy sample in this study, showed concordant results with the CWTsection (kappa = 0.836). Conclusions: We suggest that fascin immunoreactivity may identify the subsets of peripheral adenocarcinomas of the lung 3 cm or less in diameter that have a different potential to metastasize to the regional lymph nodes. The evaluation of fascin immunoreactivity on the preoperative biopsy sample could be a novel therapeutic strategy for selecting the most appropriate therapy for small-size pulmonary adenocarcinomas. (c) 2006 Elsevier B.V. All rights reserved.