Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims
Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims
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DOI：
10.1016/s0006-3223(00)00896-9
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发表时间：
2000-11-01
影响因子：
10.6
通讯作者：
Spoonster, E
中科院分区：
文献类型：
--
作者：
Delahanty, DL;Raimonde, AJ;Spoonster, E
背景资料：本研究的目的是探讨尿激素水平之间的关系，入院后的创伤单位后，机动车事故和创伤后应激障碍pharmacology.Methods：15小时尿样收集63名男性和36名女性机动车事故受害者，并被用来评估反映围创伤和急性期创伤后水平的儿茶酚胺和皮质醇水平。存在的创伤后应激障碍pneumatology进行了评估，一个月后accident.Results：机动车事故的受害者随后被诊断为急性创伤后应激障碍排泄显着较低水平的皮质醇在15小时的尿液收集入院后。此外，尿皮质醇水平预测的侵入性和回避性的想法，我一个月后的事故，结论：我们的研究结果表明，最初的皮质醇水平在创伤事件后立即作出贡献，在一定程度上，随后的创伤后应激障碍的症状的方差的显着百分比。(C)2000年生物精神病学学会
Background: This study was designed to examine the relationship between urinary hormone levels collected upon admission to the trauma unit following a motor vehicle accident and posttraumatic stress disorder symptomatology I month later.Methods: Fifteen-hour urine samples were collected from 63 male and 36 female motor vehicle accident victims and were used to assess levels of catecholamines and cortisol reflecting peritraumatic and acute-phase posttraumatic levels. Presence of posttraumatic stress disorder symptomatology was assessed I month after the accident.Results: Motor vehicle accident victims subsequently diagnosed with acute posttraumatic stress disorder excreted significantly lower levels of cortisol in 15-hour urines collected upon admission to the hospital. In addition, urinary levels of cortisol predicted a significant percentage of the variance in intrusive and avoidant thoughts I month after the accident,Conclusions: The results of our study suggest that initial cortisol levels in the immediate aftermath of a traumatic event contribute, in part, to subsequent symptoms of posttraumatic stress disorder. (C) 2000 Society of Biological Psychiatry