IDENTIFICATION OF GENES THAT INTERACT WITH THE SINA GENE IN DROSOPHILA EYE DEVELOPMENT
IDENTIFICATION OF GENES THAT INTERACT WITH THE SINA GENE IN DROSOPHILA EYE DEVELOPMENT
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DOI：
10.1073/pnas.91.24.11689
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发表时间：
1994-11-22
影响因子：
11.1
通讯作者：
RUBIN, GM
中科院分区：
文献类型：
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作者：
CARTHEW, RW;NEUFELD, TP;RUBIN, GM
sina 基因编码果蝇眼中 R7 感光细胞正确发育所需的核蛋白。我们对降低新浪活动的突变进行了基因筛查，发现了定义九个基因的突变，这些基因的产物可能是正常新浪活动所必需的。其中三个基因似乎对于 R7 细胞中 Sevenless-Ras 途径的信号传导也至关重要，其中一个基因对应于卷起的基因座 (rl)。已知 rl 基因编码 Ras 信号传导所必需的丝裂原激活蛋白激酶。这些结果表明，这三个基因的产物可能参与涉及 Ras 和 Sina 的信号传导途径，可能是通过功能性连接这两种蛋白质来实现的。
The sina gene encodes a nuclear protein that is required for the correct development of R7 photoreceptor cells in the Drosophila eye. We conducted a genetic screen for mutations that reduce the activity of sina and found mutations that define nine genes whose products may be required for normal sina activity. Three of these genes also appear to be essential for signaling by the Sevenless-Ras pathway in R7 cells, of which one gene corresponds to the rolled locus (rl). The rl gene is known to encode a mitogen-activated protein kinase necessary for signaling by Ras. These results suggest that the products of these three genes may participate in a signaling pathway involving both Ras and Sina, possibly by functionally linking these two proteins.