A 3D-printed phantom for quality-controlled reproducibility measurements of arterial spin labeled perfusion.
A 3D-printed phantom for quality-controlled reproducibility measurements of arterial spin labeled perfusion.
复制标题
3D 打印模型，用于对动脉旋转标记灌注进行质量控制的可重复性测量。
DOI：
10.1002/mrm.29886
复制
发表时间：
2024
影响因子：
3.3
通讯作者：
Madhuranthakam,AnanthJ
中科院分区：
文献类型：
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作者：
Wang,Yiming;Greer,JoshuaS;Zhou,Limin;Lin,Sheng-Qing;Hulsey,KeithM;Udayakumar,Durga;Madhuranthakam,AnanthJ
目的研制一种便携式磁共振灌注体模，用于动脉自旋标记(ASL)灌注测量的质量控制和重复性。方法研制一种3D打印的灌注体模，模拟动脉血管的分支、毛细血管和含有代表组织特征的纤维海绵的腔室。蠕动泵通过模体循环蒸馏水，最初评估的速度分别为300、400和500 毫升/分钟。使用2D伪连续ASL在20个标记后延迟(PLD，范围在0.2~7.8 S之间，间隔0.4-S)进行纵向可重复性灌流，持续16 周，每周重复3次。多个PLD数据被拟合到一个用于血流灌注量(F)和动脉通过时间(ATT)的通用动力学模型。结果在3D打印的灌注体模中获得的MR灌注信号与实验条件符合良好，信号强度逐渐增加，泵的流速在30 0~5 0 0 m L/m in时，ATT逐渐减小。在插入和间隔重复性方面，所有PLD在400min时的灌注信号以及基于一般动力学模型的f图和 图都是相似的。在所有48个实验时间点上，平均f为75.5 5 ± 3.83 × 10−3 m L/mL/S，相应的ATT为2.10 ± 0.2 0 S，T1为1.84 ± 0.102 S。组内相关系数分别为0.92(95%可信区间0.83~0.97)、0.96(0.91~0.99)和0.94(0.88~0.98)，具有良好的重复性便携式3D打印的灌注模体具有良好的2D伪连续ASL测量的重复性，可以用于ASL灌注的质量控制和可靠的测量。
PurposeTo develop a portable MR perfusion phantom for quality‐controlled assessment and reproducibility of arterial spin labeled (ASL) perfusion measurement.MethodsA 3D‐printed perfusion phantom was developed that mimics the branching of arterial vessels, capillaries, and a chamber containing cellulose sponge representing tissue characteristics. A peristaltic pump circulated distilled water through the phantom, and was first evaluated at 300, 400, and 500 mL/min. Longitudinal reproducibility of perfusion was performed using 2D pseudo‐continuous ASL at 20 post‐label delays (PLDs, ranging between 0.2 and 7.8 s at 0.4‐s intervals) over a period of 16 weeks, with three repetitions each week. Multi‐PLD data were fitted into a general kinetic model for perfusion quantification (f) and arterial transit time (ATT). Intraclass correlation coefficient was used to assess intersession reproducibility.ResultsMR perfusion signals acquired in the 3D‐printed perfusion phantom agreed well with the experimental conditions, with progressively increasing signal intensities and decreasing ATT for pump flow rates from 300 to 500 mL/min. The perfusion signal at 400 mL/min and the general kinetic model–derived f and ATT maps were similar across all PLDs for both intrasession and intersession reproducibility. Across all 48 experimental time points, the average f was 75.55 ± 3.83 × 10−3mL/mL/s, the corresponding ATT was 2.10 ± 0.20 s, and the T1was 1.84 ± 0.102 s. Intraclass correlation coefficient was 0.92 (95% confidence interval 0.83–0.97) for f, 0.96 (0.91–0.99) for ATT, and 0.94 (0.88–0.98) for T1, demonstrating excellent reproducibility.ConclusionA simple, portable 3D‐printed perfusion phantom with excellent reproducibility of 2D pseudo‐continuous ASL measurements was demonstrated that can serve for quality‐controlled and reliable measurements of ASL perfusion.