Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: a review.
Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: a review.
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DOI：
10.1155/2010/401323
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发表时间：
2010
影响因子：
2.1
通讯作者：
Jaeggi E
中科院分区：
文献类型：
--
作者：
Hutter D;Kingdom J;Jaeggi E
直到今天，氧气在胎儿发育中的作用仍然存在争议。人们仍然认为，子宫内缺氧可能是一些已知的先天性心血管畸形的原因。在过去的二十年里，详细的研究为我们提供了新的见解，并更好地了解胚胎发生和胎儿生长。但最重要的是，它一再证明氧气在早期子宫内发育中只起次要作用。器官形成后，缺氧在妊娠中期和晚期胎儿生长时变得更加重要。本文就宫内缺氧的原因、机制及其对胎儿心血管系统的影响作一综述。
Until today the role of oxygen in the development of the fetus remains controversially discussed. It is still believed that lack of oxygen in utero might be responsible for some of the known congenital cardiovascular malformations. Over the last two decades detailed research has given us new insights and a better understanding of embryogenesis and fetal growth. But most importantly it has repeatedly demonstrated that oxygen only plays a minor role in the early intrauterine development. After organogenesis has taken place hypoxia becomes more important during the second and third trimester of pregnancy when fetal growth occurs. This review will briefly adress causes and mechanisms leading to intrauterine hypoxia and their impact on the fetal cardiovascular system.