An Overview of MYC and Its Interactome
An Overview of MYC and Its Interactome
复制标题
DOI：
10.1101/cshperspect.a014357
复制
发表时间：
2014-01-01
影响因子：
5.4
通讯作者：
Eisenman, Robert N.
中科院分区：
文献类型：
--
作者：
Conacci-Sorrell, Maralice;McFerrin, Lisa;Eisenman, Robert N.
这篇综述的目的是提供一个广泛的轮廓MYC的生物学和分子功能，以及更大的蛋白质网络MYC的运作。我们提出了一个观点，MYC作为一个传感器，整合多种细胞信号介导广泛的转录反应控制细胞行为的许多方面。我们还描述了与MYC相关的更大的转录网络，重点是MYC拮抗剂的MXD家族。最后，我们讨论的证据表明，网络已经进化了数百万年，可以追溯到动物的出现。
This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.