Neuroplasticity and behavioral effects of fluoxetine after experimental stroke
Neuroplasticity and behavioral effects of fluoxetine after experimental stroke
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实验性卒中后氟西汀的神经可塑性和行为影响
DOI：
10.3233/rnn-170725
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发表时间：
2017
影响因子：
2.8
通讯作者：
Chuansheng Zhao
中科院分区：
文献类型：
--
作者：
Yefei Sun;Xiaoyu Sun;Huiling Qu;Shanshan Zhao;Ting Xiao;Chuansheng Zhao
大脑可以自我修复，并有能力弥补中风后失去的功能。脑缺血的可塑性受到几个因素的影响，包括衰老和药物治疗。氟西汀是一种抗抑郁药，它通过选择性地抑制神经元对5-羟色胺的重摄取来增强5-羟色胺能神经传递。在临床实践中，氟西汀可缓解卒中后抑郁(PSD)症状，帮助卒中患者运动功能恢复。在动物实验中，长期给予氟西汀可增加成熟颗粒细胞(GC)的兴奋性，促进齿状核(DG)的轴突和树突重组，并促进神经发生或血管生成，但氟西汀在脑室下区(SVZ)的作用仍存在争议。同时，慢性应用氟西汀并不能逆转DG中随年龄增长的细胞增殖抑制。有趣的是，虽然已经发现氟西汀可以促进中风大鼠DG的神经再生，但这一特性与行为恢复并不一致。需要对这个问题进行更多的研究，以揭示如何将增强的神经元可塑性转化为行为益处。本文就临床和实验结果中有关氟西汀的神经发生和新生细胞的命运，以及其促进卒中后行为恢复的能力的最新知识进行综述，并试图确定氟西汀在再生神经科学中的治疗特性。
The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity.of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant.which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. In clinical.practice, fluoxetine alleviates the symptoms of post-stroke depression (PSD), helps motor recovery in stroke patients. In animal.experiments£¬chronic administration of fluoxetine induces increased excitability of mature granule cells (GCs), enhancing.axonal and dendritic reorganization, as well as promoting neurogenesis or angiogenesis in the dentate gurus (DG), but the.effect of fluoxetine in the subventricular zone (SVZ) remains controversial. Meanwhile, chronic treatment with fluoxetine.did not reverse age-dependent suppression of proliferation cells in the DG. Interestingly, although fluoxetine has been found.to enhance neurogenesis in the DG in stroke rats, this property is not consistent with the behavioral recovery. More studies.into this issue will be required to reveal how to translate enhanced neuronal plasticity into behavioral benefits. This review.provides an update of the current knowledge about the neurogenesis and the fate of the newly generated cells after the use of.fluoxetine, as well as its ability to promote a behavioral recovery after stroke in clinical and experimental results and attempts to define the therapeutic properties of fluoxetine in regenerative neuroscience.