Light-emitting diodes as a light source for intraoperative photodynamic therapy
Light-emitting diodes as a light source for intraoperative photodynamic therapy
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DOI：
10.1097/00006123-199603000-00025
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发表时间：
1996-03-01
期刊：
影响因子：
4.8
通讯作者：
Whelan, HT
中科院分区：
文献类型：
--
作者：
Schmidt, MH;Bajic, DM;Whelan, HT
开发更经济有效的光源用于脑肿瘤的光动力治疗将有利于研究和临床应用。在这项研究中，使用发光二极管阵列的光动力疗法的脑肿瘤与Photofrin porfimer钠进行了调查。构造了具有发光二极管（LED）尖端的可充气球囊装置。这些发光二极管是基于新的半导体砷化铝镓。它们可以在高功率水平下发射宽光谱红光，峰值波长为677 nm，带宽为25 nm。用0.1%的intraperoid充盈球囊，intraperoid用作光散射介质。在几个点的光通量的测量显示出高度的光分散。然后将该探针的光谱发射与Photofrin的吸收光谱进行比较。该分析表明，Photofrin使用LED光源时吸收的光是使用单色630 nm光时吸收的光的27.5%。因此，为了实现与激光光源的能量光剂量相等的能量光剂量，LED光输出必须增加3.63倍。这种对额外能量的需求是Photofrin在630和677 nm吸收之间的差异。使用LED探头和激光球囊适配器，对犬脑干毒性进行了比较。LED和激光在相同的光能和Photofrin剂量下显示出相同的毒性迹象。Photofrin的最大耐受剂量为1.6 mg/kg，使用100 J/cm（2）的激光或LED光能。本研究的结论是，LED是一个合适的光源与Photofrin脑肿瘤的光动力治疗。此外，LED具有成为第二代光敏剂的高效光源的潜力，其吸收波长更接近LED峰值发射。
THE DEVELOPMENT OF more cost-effective light sources for photodynamic therapy of brain tumors would be of benefit for both research and clinical applications. In this study, the use of light-emitting diode arrays for photodynamic therapy of brain tumors with Photofrin porfimer sodium was investigated. An inflatable balloon device with a light-emitting diode (LED) tip was constructed. These LEDs are based on the new semiconductor aluminum gallium arsenide. They can emit broad-spectrum red light at high power levels with a peak wavelength of 677 nm and a bandwidth of 25 nm. The balloon was inflated with 0.1% intralipid, which served as a light-scattering medium. Measurements of light flux at several points showed a high degree of light dispersion. The spectral emission of this probe was then compared with the absorption spectrum of Photofrin. This analysis showed that the light absorbed by Photofrin with the use of the LED source was 27.5% of that absorbed with the use of the monochromatic 630-nm light. Thus, to achieve an energy light dose equivalent to that of a laser light source, the LED light output must he increased by a factor of 3.63. This need for additional energy is the difference between a 630- and 677-nm absorption of Photofrin. Using the LED probe and the laser balloon adapter, a comparison of brain stem toxicity in canines was conducted. LED and laser light showed the same signs of toxicity at equivalent light energy and Photofrin doses. The maximal tolerated dose of Photofrin was 1.6 mg/kg, using 100 J/cm(2) of light energy administered by laser or LED. This study concludes that LEDs are a suitable light source for photodynamic therapy of brain tumors with Photofrin. In addition, LEDs have the potential to be highly efficient light sources for second-generation photosensitizers with absorption wavelengths closer to the LED peak emission.