Longitudinal influence of age, menopause, hormone replacement therapy, and other medications on parotid flow rates in healthy women.
Longitudinal influence of age, menopause, hormone replacement therapy, and other medications on parotid flow rates in healthy women.
复制标题
年龄、更年期、激素替代疗法和其他药物对健康女性腮腺流量的纵向影响。
DOI：
10.1093/gerona/55.1.m34
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Ship,JA
中科院分区：
文献类型：
--
作者：
Ghezzi,EM;Wagner-Lange,LA;Schork,MA;Metter,EJ;Baum,BJ;Streckfus,CF;Ship,JA
背景技术背景：最近的研究表明，腮腺唾液腺功能障碍不是正常的衰老过程，而可能是全身性疾病及其治疗的结果，包括药物治疗和绝经。本研究的目的是纵向评估年龄、绝经状态、激素替代治疗和其他药物对健康女性腮腺刺激流速（SPFR）的影响。方法：医学诊断、绝经状态、药物使用和2%柠檬酸刺激的腮腺唾液收集自巴尔的摩老龄化纵向研究（国家老龄化研究所，国立卫生研究院）的396名年龄在21 - 96岁的妇女，时间跨度为17年。结果：SPFR无时间效应。当调整时间和口腔干燥药物时，首次就诊时的年龄是SPFR降低的重要预测因素。然而，服用一种口腔干燥药物的有害影响相当于大约14岁的衰老。绝经状态和激素替代治疗与SPFR降低并不一致。结论：这些结果表明绝经和激素替代治疗与腮腺唾液分泌功能障碍无关。衰老可能对SPFR有统计学显著但很小的有害影响;然而，口腔干燥药物的不良影响要大得多。
BACKGROUND: Recent investigations have demonstrated that parotidsalivary dysfunction is not a normal process of aging, but may be theconsequence of systemic conditions and their treatment, includingmedications and menopause. The purpose of this study was to assesslongitudinally the influence of age, menopausal status, hormone replacementtherapy, and other medications on stimulated parotid flow rates (SPFRs) inhealthy women. METHODS: Medical diagnoses, menopausal status, medicationutilization, and 2% citric acid stimulated parotid salivas were collectedfrom 396 women, aged 21 to 96 years, from the Baltimore Longitudinal Studyof Aging (National Institute on Aging, National Institutes of Health) overa 17-year span by three investigators. RESULTS: There was no overalllongitudinal effect of time on SPFR. Age at first visit was a significantpredictor of a decrease in SPFR when adjusted for time and xerostomicmedications. However, the deleterious effect of taking one xerostomicmedication was equivalent to approximately 14 years of aging. Menopausalstatus and hormone replacement therapy were not consistently associatedwith diminished SPFR. CONCLUSIONS: These results suggest that menopause andhormone replacement therapy are not associated with parotid salivarydysfunction. Aging may have a statistically significant yet smalldeleterious influence on SPFR; however, the adverse influence of xerostomicmedications is much larger.