Protein arginine methylation in health and disease
Protein arginine methylation in health and disease
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DOI：
10.1016/s1387-2656(08)00008-2
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Hu, John C.
中科院分区：
文献类型：
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作者：
Aletta, John M.;Hu, John C.
蛋白质精氨酸甲基化是生物医学研究的一个快速发展的领域，它对扩展我们对发育和病理过程的理解有很大的希望。不到10年前，只有不到24种蛋白质被证实含有甲基精氨酸。然而，目前已经检测到数百种甲基精氨酸蛋白，其中许多已通过质谱和其他蛋白质组学和分子技术得到证实。这些蛋白质中有几种是疾病基因的产物，或者通过最近的实验或临床观察与疾病过程有关。本章的目的是双重的;（1）重新检查蛋白质精氨酸甲基化的作用，放置在细胞生长和分化的背景下，以及在丰富的细胞代谢甲基化途径和（2）审查的影响，最近的进展，蛋白质甲基精氨酸检测和蛋白质甲基精氨酸功能的分析，我们对人类疾病的理解。
Protein arginine methylation is a rapidly growing field of biomedical research that holds great promise for extending our understanding of developmental and pathological processes. Less than ten years ago, fewer than two dozen proteins were verified to contain methylarginine. Currently, however, hundreds of methylarginine proteins have been detected and many have been confirmed by mass spectrometry and other proteomic and molecular techniques. Several of these proteins are products of disease genes or are implicated in disease processes by recent experimental or clinical observations. The purpose of this chapter is twofold; (1) to re-examine the role of protein arginine methylation placed within the context of cell growth and differentiation, as well as within the rich variety of cellular metabolic methylation pathways and (2) to review the implications of recent advances in protein methylarginine detection and the analysis of protein methylarginine function for our understanding of human disease.