Role of the cerebellum in externally paced rhythmic finger movements
Role of the cerebellum in externally paced rhythmic finger movements
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DOI：
10.1152/jn.01088.2006
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发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Rothwell, John C.
中科院分区：
文献类型：
--
作者：
Fernandez Del Olmo, Miguel;Cheeran, Binith;Rothwell, John C.
一些研究表明，小脑在亚秒间隔的计时中起着重要作用。以前的研究使用经颅磁刺激（TMS）直接测试这一假设产生了不一致的结果。在这里，我们使用1-Hz重复TMS（rTMS）10分钟左右的小脑半球短暂干扰小脑处理，以评估其对手指敲击任务的性能的影响。受试者用右手食指敲击1分钟（同步阶段），听觉或视觉提示在0.5，1，或2 Hz;他们继续在没有提示的情况下，以相同的速度再持续1分钟（继续阶段）。以随机顺序进行试验区组。rTMS的同侧的小脑的运动增加了intertap间隔的变异性，但只有在2 Hz的运动，而受试者同步的听觉线索。当线索不再存在或与视觉线索同步时，对任务的继续阶段没有影响。刺激对侧背侧运动前皮层后观察到类似的结果，但在辅助运动区的rTMS后观察不到。rTMS对同侧右颈神经根或同侧初级运动皮层无影响。研究结果支持了亚秒级事件相关计时的神经网络假说，该假说涉及小脑-运动前区网络。
Several studies have suggested that the cerebellum has an important role in timing of subsecond intervals. Previous studies using transcranial magnetic stimulation (TMS) to test this hypothesis directly have produced inconsistent results. Here we used 1-Hz repetitive TMS ( rTMS) for 10 min over the right or left cerebellar hemisphere to interfere transiently with cerebellar processing to assess its effect on the performance of a finger-tapping task. Subjects tapped with their right index finger for 1 min ( synchronization phase) with an auditory or visual cue at 0.5, 1, or 2 Hz; they continued for a further 1 min at the same rate with no cues ( continuation phase). The blocks of trials were performed in a random order. rTMS of the cerebellum ipsilateral to the movement increased the variability of the intertap interval but only for movements at 2 Hz that were made while subjects were synchronizing with an auditory cue. There was no effect on the continuation phase of the task when the cues were no longer present or on synchronization with a visual cue. Similar results were seen after stimulation over the contralateral dorsal premotor cortex but not after rTMS over supplementary motor area. There was no effect after rTMS over the ipsilateral right cervical nerve roots or over the ipsilateral primary motor cortex. The results support the hypothesis of neural network for event-related timing in the subsecond range that involves a cerebellar-premotor network.