Anthrax pathogenesis and host response.
Anthrax pathogenesis and host response.
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DOI：
10.1007/978-3-642-80451-9_2
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发表时间：
1998
影响因子：
--
通讯作者：
P. Hanna
中科院分区：
文献类型：
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作者：
P. Hanna
世纪以来，炭疽一直是传染病研究的一个祸害和基本模型。与全身性炭疽相关的死亡在用炭疽致死毒素攻击的动物中被模仿，炭疽致死毒素是一种被认为只影响巨噬细胞的毒力因子。耗尽巨噬细胞的动物变得对毒素有抵抗力，而将培养的巨噬细胞重新引入耗尽的动物中可以恢复敏感性。这些研究和其他研究暗示了先天免疫系统在炭疽病患者死亡中的积极作用。许多分子因素和事件
Anthrax has been both a scourge and a fundamental model for infectious disease studies for over a century. Death associated with systemic anthrax is mimicked in animals challenged with anthrax lethal toxin, a virulence factor believed to affect only macrophages. Animals depleted of macro phages become resistant fo the toxin, while reintroduction of cultured macrophages into depleted animals restores sensitivity. These studies and others implicate an active role for the innate immune system in the demise of the anthrax victim. Many of the molecular factors and events