The Diverse Ethics of Translational Research
The Diverse Ethics of Translational Research
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DOI：
10.1080/15265161.2010.494214
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发表时间：
2010-01-01
影响因子：
13.4
通讯作者：
Eyal, Nir
中科院分区：
文献类型：
--
作者：
Sofaer, Neema;Eyal, Nir
翻译研究伦理学的评论家们发现它在道德上是有问题的。翻译研究的类型据说涉及可疑的利益，特殊的风险，知情同意的额外障碍和严重的利益冲突。对全球穷人进行的转化研究被认为是在剥削他们，扩大国际差距。一些评论家支持特别严格的伦理审查。然而，这种担忧仅基于批准前的转化研究（现在称为T1）。无论T1是否具有这些特征，超出批准范围的转化研究（T2：第四阶段，卫生服务和实施研究）都不太可能支持发展，并且在对全球穷人进行时可能支持发展。因此，只要T1在道德上是有问题的，并且不存在对T2的独立反对意见，翻译研究的伦理就多种多样：虽然有些翻译研究是有问题的，但有些不是。供资和监督应反映这种多样性，应鼓励T2，特别是在全球穷人中进行。
Commentators on the ethics of translational research find it morally problematic. Types of translational research are said to involve questionable benefits, special risks, additional barriers to informed consent, and severe conflicts of interest. Translational research conducted on the global poor is thought to exploit them and increase international disparities. Some commentators support especially stringent ethical review. However, such concerns are grounded only in pre-approval translational research (now called T1). Whether or not T1 has these features, translational research beyond approval (T2: phase IV, health services, and implementation research) is unlikely to and, when conducted on the global poor, may support development. Therefore, insofar as T1 is morally problematic, and no independent objections to T2 exist, the ethics of translational research is diverse: while some translational research is problematic, some is not. Funding and oversight should reflect this diversity, and T2 should be encouraged, particularly when conducted among the global poor.