Combination of photodynamic therapy (PDT) and anti-tumor immunity in cancer therapy
Combination of photodynamic therapy (PDT) and anti-tumor immunity in cancer therapy
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DOI：
10.1007/s40005-017-0377-x
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发表时间：
2018-03-01
影响因子：
5.5
通讯作者：
Na, Kun
中科院分区：
文献类型：
--
作者：
Hwang, Hee Sook;Shin, Heejun;Na, Kun
光动力疗法（PDT）是在有氧的情况下使用光敏剂和特定波长的光在癌细胞中产生单线态氧和活性氧（ROS）来进行的。靶位点积累的光敏剂在光激活下诱导ROS产生，然后产生的细胞毒性活性氧导致肿瘤细胞通过凋亡或坏死而死亡，并损伤靶位点从而导致肿瘤破坏。因此，PDT 介导的细胞死亡与抗肿瘤免疫反应相关。本文就PDT和免疫反应对肿瘤的影响进行综述。还讨论了与先天性和适应性免疫反应相关的免疫反应的激活、与 PDT 抗肿瘤功效相关的免疫细胞和肿瘤细胞的相互作用。
Photodynamic therapy (PDT) is performed using a photosensitizer and light of specific wavelength in the presence of oxygen to generate singlet oxygen and reactive oxygen species(ROS) in the cancer cells. The accumulated photosensitizers in target sites induce ROS generation upon light activation, then the generated cytotoxic reactive oxygen species lead to tumor cell death via apoptosis or necrosis, and damages the target sites which results tumor destruction. As a consequence, the PDT-mediated cell death is associated with anti-tumor immune response. In this paper, the effects of PDT and immune response on tumors are reviewed. Activation of an immune response regarding the innate and adaptive immune response, interaction with immune cells and tumor cells that associated with antitumor efficacy of PDT are also discussed.