RANDOMIZED TRIAL OF TREATMENT OF HYPERTENSION IN ELDERLY PATIENTS IN PRIMARY CARE
RANDOMIZED TRIAL OF TREATMENT OF HYPERTENSION IN ELDERLY PATIENTS IN PRIMARY CARE
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DOI：
10.1136/bmj.293.6555.1145
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发表时间：
1986-11-01
影响因子：
--
通讯作者：
WARRENDER, TS
中科院分区：
文献类型：
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作者：
COOPE, J;WARRENDER, TS
一项在884名发病时年龄在60至79岁之间的高血压患者中进行的随机试验显示，在平均4.4年的随访期内，血压降低了18/11 mm Hg。主要降压药为阿替洛尔和苄氟肼。治疗组的致死性卒中发生率降低至对照组的30%（95%置信区间11- 84%，p <0.025）。治疗组的所有卒中（致死性和非致死性）发生率为对照组的58%（95%置信区间35- 96%，p <0.03）。心肌梗死的发生率和总死亡率不受治疗的影响。由患者及其亲属完成的问卷调查未能发现任何可能因治疗而导致的症状差异。
A randomised trial of the treatment of hypertension in 884 patients aged 60 to 79 years at the onset showed a reduction of 18/11 mm Hg in blood pressure over a mean follow up period of 4.4 years. The principal antihypertensive agents were atenolol and bendrofluazide. There was a reduction in the rate of fatal stroke in the treatment group to 30% of that in the control group (95% confidence interval 11-84%, p less than 0.025). The rate of all strokes (fatal and non-fatal) in the treatment group was 58% of that in the control group (95% confidence interval 35-96%, p less than 0.03). The incidence of myocardial infarction and total mortality was unaffected by treatment. Questionnaires completed by the patients and their relatives failed to identify any differences in symptoms that were likely to be due to treatment.