Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity
Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity
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DOI：
10.1016/s1383-5718(00)00096-6
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发表时间：
2000-10-10
影响因子：
1.9
通讯作者：
Saini, A
中科院分区：
文献类型：
--
作者：
Kaur, IP;Saini, A
芝麻油是一种酚类化合物，与其他植物油相比，芝麻油具有较高的抗氧化变质性。研究人员对不同鼠伤寒沙门氏菌菌株进行诱变剂处理后，研究了芝麻油的作用。Sesamol在Ames试验菌株TA100和TA102中表现出较强的抗诱变作用。TA102菌株已被证明对活性氧非常敏感。叔丁基过氧化氢（t-BOOH）或过氧化氢（H2O2）产生氧自由基诱导诱变；因此，芝麻酚的抗诱变特性可归因于其抗氧化特性。超氧化物和羟基自由基清除能力已进一步阐明使用体外试验系统。进一步证明了它对t- booh诱变TA102菌株具有去突变作用。芝麻酚还能抑制叠氮化钠（na -叠氮化钠）对TA100试验菌株的诱变作用，而对硝基喹啉- n -氧化物（NQNO）诱导的鼠伤寒沙门菌TA98菌株的诱变作用没有影响。自活性氧谱；Ies参与了多个阶段的致癌性过程，该化合物也可能表现出抗癌特性。(C) 2000 Elsevier Science B.V.版权所有
The effects of sesamol, a phenolic compound responsible for the high resistance of sesame oil to oxidative deterioration as compared with other vegetable oils, have been investigated after mutagen treatment in various strains of Salmonella typhimurium. Sesamol was shown to exhibit strong antimutagenic effects in the Ames tester strains TA100 and TA102. The TA102 strain has been shown to be highly sensitive to reactive oxygen species. Mutagenicity was induced by the generation of oxygen radicals by tert-butylhydroperoxide (t-BOOH) or hydrogen peroxide (H2O2); therefore, the antimutagenic property of sesamol was attributed to its antioxidant properties. The superoxide and hydroxyl radical scavenging capabilities have further been elucidated using in vitro test systems. It was further shown to have a desmutagenic effect on t-BOOH-induced mutagenesis in TA102 strain. Sesamol also inhibited the mutagenicity of sodium azide (Na-azide) in TA100 tester strain while it had no effect on nitroquinoline-N-oxide (NQNO)-induced mutagenesis in TA98 strain of Salmonella typhimurium. Since active oxygen spec;ies are involved in multiple stage processes of carcinogenicity, this compound may also exhibit anticarcinogenic properties. (C) 2000 Elsevier Science B.V. All rights reserved.